Identity
HGNC
LOCATION
1q25.1
LOCUSID
ALIAS
FHL6,IMDSHY,RNF198,ROQUIN
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 149041
MIM: 609424
HGNC: 29434
Ensembl: ENSG00000135870
Variants:
dbSNP: 149041
ClinVar: 149041
TCGA: ENSG00000135870
COSMIC: RC3H1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000135870 | ENST00000258349 | Q5TC82 |
| ENSG00000135870 | ENST00000367694 | Q5TC82 |
| ENSG00000135870 | ENST00000367696 | Q5TC82 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36920923 | 2023 | Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells. | 20 |
| 36920923 | 2023 | Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells. | 20 |
| 35999072 | 2022 | miR-150 promotes progressive T cell differentiation via inhibiting FOXP1 and RC3H1. | 3 |
| 35999072 | 2022 | miR-150 promotes progressive T cell differentiation via inhibiting FOXP1 and RC3H1. | 3 |
| 35082795 | 2021 | Dynamic Regulation of the Nexus Between Stress Granules, Roquin, and Regnase-1 Underlies the Molecular Pathogenesis of Warfare Vesicants. | 5 |
| 35082795 | 2021 | Dynamic Regulation of the Nexus Between Stress Granules, Roquin, and Regnase-1 Underlies the Molecular Pathogenesis of Warfare Vesicants. | 5 |
| 32446391 | 2020 | MAP7 interacts with RC3H1 and cooperatively regulate cell-cycle progression of cervical cancer cells via activating the NF-κB signaling. | 9 |
| 32491174 | 2020 | Structural basis for the recognition of transiently structured AU-rich elements by Roquin. | 6 |
| 33228782 | 2020 | Roquin1 inhibits the proliferation of breast cancer cells by inducing G1/S cell cycle arrest via selectively destabilizing the mRNAs of cell cycle-promoting genes. | 7 |
| 32446391 | 2020 | MAP7 interacts with RC3H1 and cooperatively regulate cell-cycle progression of cervical cancer cells via activating the NF-κB signaling. | 9 |
| 32491174 | 2020 | Structural basis for the recognition of transiently structured AU-rich elements by Roquin. | 6 |
| 33228782 | 2020 | Roquin1 inhibits the proliferation of breast cancer cells by inducing G1/S cell cycle arrest via selectively destabilizing the mRNAs of cell cycle-promoting genes. | 7 |
| 31451648 | 2019 | Human cytomegalovirus induces and exploits Roquin to counteract the IRF1-mediated antiviral state. | 11 |
| 31451648 | 2019 | Human cytomegalovirus induces and exploits Roquin to counteract the IRF1-mediated antiviral state. | 11 |
| 29352114 | 2018 | Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. | 19 |
Citation
Dessen P
RC3H1 (ring finger and CCCH-type domains 1)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56174/rc3h1-(ring-finger-and-ccch-type-domains-1)
