SLC39A7 (solute carrier family 39 member 7)

2016-10-01  

Identity

HGNC
LOCATION
6p21.32
LOCUSID
ALIAS
D6S115E,D6S2244E,H2-KE4,HKE4,KE4,RING5,ZIP7
FUSION GENES

Other Information

Locus ID:

NCBI: 7922
MIM: 601416
HGNC: 4927
Ensembl: ENSG00000112473

Variants:

dbSNP: 7922
ClinVar: 7922
TCGA: ENSG00000112473
COSMIC: SLC39A7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112473ENST00000374675Q92504
ENSG00000112473ENST00000374675A0A024RCX7
ENSG00000112473ENST00000374677Q92504
ENSG00000112473ENST00000374677A0A024RCX7
ENSG00000112473ENST00000444757A2AAT0

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc influx into cells by the SLC39 gene familyREACTOMER-HSA-442380

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
335351842021Evaluation of the prognostic values of solute carrier (SLC) family 39 genes for patients with lung adenocarcinoma.9
336085082021Zinc transporter ZIP7 is a novel determinant of ferroptosis.40
335351842021Evaluation of the prognostic values of solute carrier (SLC) family 39 genes for patients with lung adenocarcinoma.9
336085082021Zinc transporter ZIP7 is a novel determinant of ferroptosis.40
321092902020SLC39A7, regulated by miR-139-5p, induces cell proliferation, migration and inhibits apoptosis in gastric cancer via Akt/mTOR signaling pathway.9
326450592020Zinc transporter SLC39A7 relieves zinc deficiency to suppress alternative macrophage activation and impairment of phagocytosis.5
321092902020SLC39A7, regulated by miR-139-5p, induces cell proliferation, migration and inhibits apoptosis in gastric cancer via Akt/mTOR signaling pathway.9
326450592020Zinc transporter SLC39A7 relieves zinc deficiency to suppress alternative macrophage activation and impairment of phagocytosis.5
302375092019Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking.17
307189142019An essential role for the Zn(2+) transporter ZIP7 in B cell development.51
307813502019Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes.14
314834182019Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer.13
302375092019Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking.17
307189142019An essential role for the Zn(2+) transporter ZIP7 in B cell development.51
307813502019Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes.14

Citation

Dessen P

SLC39A7 (solute carrier family 39 member 7)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56175/slc39a7-(solute-carrier-family-39-member-7)