MCHR1 (melanin concentrating hormone receptor 1)

2016-10-01  

Identity

HGNC
LOCATION
22q13.2
LOCUSID
ALIAS
GPR24,MCH-1R,MCH1R,SLC-1,SLC1
FUSION GENES

Other Information

Locus ID:

NCBI: 2847
MIM: 601751
HGNC: 4479
Ensembl: ENSG00000128285

Variants:

dbSNP: 2847
ClinVar: 2847
TCGA: ENSG00000128285
COSMIC: MCHR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128285ENST00000249016Q99705
ENSG00000128285ENST00000381433A6ZJ87

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
BBSome-mediated cargo-targeting to ciliumREACTOMER-HSA-5620922
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
349123332021PDGF Promotes Dermal Fibroblast Activation via a Novel Mechanism Mediated by Signaling Through MCHR1.8
349123332021PDGF Promotes Dermal Fibroblast Activation via a Novel Mechanism Mediated by Signaling Through MCHR1.8
315639482020Melanin Concentrating Hormone Signaling Deficits in Schizophrenia: Association With Memory and Social Impairments and Abnormal Sensorimotor Gating.9
315639482020Melanin Concentrating Hormone Signaling Deficits in Schizophrenia: Association With Memory and Social Impairments and Abnormal Sensorimotor Gating.9
243056792014Melanin-concentrating hormone receptor 1 polymorphisms are associated with components of energy balance in the Complex Diseases in the Newfoundland Population: Environment and Genetics (CODING) study.15
243056792014Melanin-concentrating hormone receptor 1 polymorphisms are associated with components of energy balance in the Complex Diseases in the Newfoundland Population: Environment and Genetics (CODING) study.15
220810642012The gene encoding the melanin-concentrating hormone receptor 1 is associated with schizophrenia in a Danish case-control sample.6
221540492012Microarray-based mutation detection of pediatric sporadic nonsyndromic hearing loss in China.4
220810642012The gene encoding the melanin-concentrating hormone receptor 1 is associated with schizophrenia in a Danish case-control sample.6
221540492012Microarray-based mutation detection of pediatric sporadic nonsyndromic hearing loss in China.4
216373412011Allele-specific, age-dependent and BMI-associated DNA methylation of human MCHR1.17
216373412011Allele-specific, age-dependent and BMI-associated DNA methylation of human MCHR1.17
206331392010Functional interaction of regulator of G protein signaling-2 with melanin-concentrating hormone receptor 1.1
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.57
208337952010Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling.3

Citation

Dessen P

MCHR1 (melanin concentrating hormone receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56204/mchr1-(melanin-concentrating-hormone-receptor-1)