PDE1A (phosphodiesterase 1A)

2016-10-01 Affiliation

Identity

HGNC

PDE1A

LOCATION

2q32.1

LOCUSID

5136

ALIAS

CAM-PDE

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5136
MIM: 171890
HGNC: 8774
Ensembl: ENSG00000115252

Variants:

dbSNP: 5136
ClinVar: 5136
TCGA: ENSG00000115252
COSMIC: PDE1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115252	ENST00000351439	P54750
ENSG00000115252	ENST00000358139	P54750
ENSG00000115252	ENST00000409365	P54750
ENSG00000115252	ENST00000410103	P54750
ENSG00000115252	ENST00000435564	P54750

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Calcium signaling pathway	KEGG	ko04020
Olfactory transduction	KEGG	ko04740
Taste transduction	KEGG	ko04742
Purine metabolism	KEGG	hsa00230
Calcium signaling pathway	KEGG	hsa04020
Olfactory transduction	KEGG	hsa04740
Taste transduction	KEGG	hsa04742
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
Renin secretion	KEGG	hsa04924
Renin secretion	KEGG	ko04924
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
DAG and IP3 signaling	REACTOME	R-HSA-1489509
CaM pathway	REACTOME	R-HSA-111997
Calmodulin induced events	REACTOME	R-HSA-111933
Cam-PDE 1 activation	REACTOME	R-HSA-111957
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Nitric oxide stimulates guanylate cyclase	REACTOME	R-HSA-392154
cGMP effects	REACTOME	R-HSA-418457
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
EGFR interacts with phospholipase C-gamma	REACTOME	R-HSA-212718
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PLC-gamma1 signalling	REACTOME	R-HSA-167021
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
Opioid Signalling	REACTOME	R-HSA-111885
G-protein mediated events	REACTOME	R-HSA-112040
PLC beta mediated events	REACTOME	R-HSA-112043
Ca-dependent events	REACTOME	R-HSA-111996

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA444552	Hypertension	Disease	Literature, MultilinkAnnotation	associated			24560520

References

Pubmed ID	Year	Title	Citations
37125963	2023	Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes.	3
37125963	2023	Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes.	3
28132591	2018	Exploring pyrazolo[3,4-d]pyrimidine phosphodiesterase 1 (PDE1) inhibitors: a predictive approach combining comparative validated multiple molecular modelling techniques.	5
28132591	2018	Exploring pyrazolo[3,4-d]pyrimidine phosphodiesterase 1 (PDE1) inhibitors: a predictive approach combining comparative validated multiple molecular modelling techniques.	5
29262781	2017	PDE1A polymorphism contributes to the susceptibility of nephrolithiasis.	2
29262781	2017	PDE1A polymorphism contributes to the susceptibility of nephrolithiasis.	2
26464516	2015	Phosphodiesterase 1 regulation is a key mechanism in vascular aging.	27
26464516	2015	Phosphodiesterase 1 regulation is a key mechanism in vascular aging.	27
20807569	2011	Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.	26
22012077	2011	Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.	45
20807569	2011	Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.	26
22012077	2011	Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.	45
20110084	2010	Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.	21
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15

Citation

Dessen P

PDE1A (phosphodiesterase 1A)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56212/pde1a-(phosphodiesterase-1a)