Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5136
MIM: 171890
HGNC: 8774
Ensembl: ENSG00000115252
Variants:
dbSNP: 5136
ClinVar: 5136
TCGA: ENSG00000115252
COSMIC: PDE1A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444552 | Hypertension | Disease | Literature, MultilinkAnnotation | associated | 24560520 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37125963 | 2023 | Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes. | 3 |
| 37125963 | 2023 | Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes. | 3 |
| 28132591 | 2018 | Exploring pyrazolo[3,4-d]pyrimidine phosphodiesterase 1 (PDE1) inhibitors: a predictive approach combining comparative validated multiple molecular modelling techniques. | 5 |
| 28132591 | 2018 | Exploring pyrazolo[3,4-d]pyrimidine phosphodiesterase 1 (PDE1) inhibitors: a predictive approach combining comparative validated multiple molecular modelling techniques. | 5 |
| 29262781 | 2017 | PDE1A polymorphism contributes to the susceptibility of nephrolithiasis. | 2 |
| 29262781 | 2017 | PDE1A polymorphism contributes to the susceptibility of nephrolithiasis. | 2 |
| 26464516 | 2015 | Phosphodiesterase 1 regulation is a key mechanism in vascular aging. | 27 |
| 26464516 | 2015 | Phosphodiesterase 1 regulation is a key mechanism in vascular aging. | 27 |
| 20807569 | 2011 | Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis. | 26 |
| 22012077 | 2011 | Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. | 45 |
| 20807569 | 2011 | Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis. | 26 |
| 22012077 | 2011 | Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. | 45 |
| 20110084 | 2010 | Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients. | 21 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
Citation
Dessen P
PDE1A (phosphodiesterase 1A)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56212/pde1a-(phosphodiesterase-1a)
