NPHP4 (nephrocystin 4)

2016-10-01  

Identity

HGNC
LOCATION
1p36.31
LOCUSID
ALIAS
POC10,SLSN4
FUSION GENES

Other Information

Locus ID:

NCBI: 261734
MIM: 607215
HGNC: 19104
Ensembl: ENSG00000131697

Variants:

dbSNP: 261734
ClinVar: 261734
TCGA: ENSG00000131697
COSMIC: NPHP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131697ENST00000378156O75161
ENSG00000131697ENST00000378169D6RA06
ENSG00000131697ENST00000466897H0YA08
ENSG00000131697ENST00000489180O75161
ENSG00000131697ENST00000622020O75161

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Signal TransductionREACTOMER-HSA-162582
Signaling by HippoREACTOMER-HSA-2028269

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378313492024A novel NPHP4 homozygous missense variant identified in infertile brothers with multiple morphological abnormalities of the sperm flagella.0
378313492024A novel NPHP4 homozygous missense variant identified in infertile brothers with multiple morphological abnormalities of the sperm flagella.0
345911602022Association of Nephronophthisis 4 genetic variation with cardiorenal syndrome and cardiovascular events in Japanese general population: the Yamagata (Takahata) study.1
345911602022Association of Nephronophthisis 4 genetic variation with cardiorenal syndrome and cardiovascular events in Japanese general population: the Yamagata (Takahata) study.1
335128962021SENIOR-LØKEN SYNDROME: A Case Series and Review of the Renoretinal Phenotype and Advances of Molecular Diagnosis.2
335128962021SENIOR-LØKEN SYNDROME: A Case Series and Review of the Renoretinal Phenotype and Advances of Molecular Diagnosis.2
318107332020Adult-Diagnosed Nonsyndromic Nephronophthisis in Australian Families Caused by Biallelic NPHP4 Variants.7
318107332020Adult-Diagnosed Nonsyndromic Nephronophthisis in Australian Families Caused by Biallelic NPHP4 Variants.7
281343402017KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.37
283924752017A familial case of severe infantile nephronophthisis explained by oligogenic inheritance.4
281343402017KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.37
283924752017A familial case of severe infantile nephronophthisis explained by oligogenic inheritance.4
235744052014NPHP4 mutation is linked to cerebello-oculo-renal syndrome and male infertility.10
235744052014NPHP4 mutation is linked to cerebello-oculo-renal syndrome and male infertility.10
225501382012NPHP4 variants are associated with pleiotropic heart malformations.22

Citation

Dessen P

NPHP4 (nephrocystin 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56220/nphp4-(nephrocystin-4)