SIDT2 (SID1 transmembrane family member 2)

2016-10-01  

Identity

HGNC
SIDT2
LOCATION
11q23.3
LOCUSID
51092
ALIAS
CGI-40
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51092
MIM: 617551
HGNC: 24272
Ensembl: ENSG00000149577

Variants:

dbSNP: 51092
ClinVar: 51092
TCGA: ENSG00000149577
COSMIC: SIDT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149577ENST00000278951C9JBG5
ENSG00000149577ENST00000324225Q8NBJ9
ENSG00000149577ENST00000431081F5H8L4
ENSG00000149577ENST00000524842E9PPN9
ENSG00000149577ENST00000525478H0YEI3
ENSG00000149577ENST00000531353E9PME7
ENSG00000149577ENST00000532062G3V172
ENSG00000149577ENST00000532960E9PMC3
ENSG00000149577ENST00000620360Q8NBJ9
ENSG00000149577ENST00000628876C9JBG5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
270462512016Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
278463652017Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes.5
279873062017Identification of Sidt2 as a lysosomal cation-conducting protein.3
287850582017A novel family of mammalian transmembrane proteins involved in cholesterol transport.3
297529552018Skeletal muscle-specific Sidt2 knockout in mice induced muscular dystrophy-like phenotype.0
303828982018Multiple genotype-phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population.0

Citation

Dessen P

SIDT2 (SID1 transmembrane family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56230/sidt2-(sid1-transmembrane-family-member-2)