MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein)

2016-10-01  

Identity

HGNC
MCIDAS
LOCATION
5q11.2
LOCUSID
345643
ALIAS
CILD42,IDAS,MCI,MCIN

Other Information

Locus ID:

NCBI: 345643
MIM: 614086
HGNC: 40050
Ensembl: ENSG00000234602

Variants:

dbSNP: 345643
ClinVar: 345643
TCGA: ENSG00000234602
COSMIC: MCIDAS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000234602ENST00000513312D6RGH6
ENSG00000234602ENST00000513468I6L8E2

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
323623812021Transcriptional regulation of multiciliated cell differentiation.38
345690652021Bi-allelic mutations in MCIDAS and CCNO cause human infertility associated with abnormal gamete transport.5
323623812021Transcriptional regulation of multiciliated cell differentiation.38
345690652021Bi-allelic mutations in MCIDAS and CCNO cause human infertility associated with abnormal gamete transport.5
250489632014MCIDAS mutations result in a mucociliary clearance disorder with reduced generation of multiple motile cilia.116
250489632014MCIDAS mutations result in a mucociliary clearance disorder with reduced generation of multiple motile cilia.116
240642112013The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing.8
240642112013The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing.8
215433322011Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression.24
215433322011Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression.24

Citation

Dessen P

MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56246/mcidas-(multiciliate-differentiation-and-dna-synthesis-associated-cell-cycle-protein)