Identity
HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
HBG-T2,HBGA,HBGR,HSGGL1,PRO2979
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3047
MIM: 142200
HGNC: 4831
Ensembl: ENSG00000213934
Variants:
dbSNP: 3047
ClinVar: 3047
TCGA: ENSG00000213934
COSMIC: HBG1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000213934 | ENST00000330597 | P69891 |
| ENSG00000213934 | ENST00000330597 | D9YZU8 |
| ENSG00000213934 | ENST00000632727 | A0A0J9YYA3 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Hemostasis | REACTOME | R-HSA-109582 |
| Factors involved in megakaryocyte development and platelet production | REACTOME | R-HSA-983231 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38218889 | 2024 | Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia. | 0 |
| 38218889 | 2024 | Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia. | 0 |
| 35138035 | 2022 | Joint efficacy of the three biomarkers SNCA, GYPB and HBG1 for atrial fibrillation and stroke: Analysis via the support vector machine neural network. | 2 |
| 35138035 | 2022 | Joint efficacy of the three biomarkers SNCA, GYPB and HBG1 for atrial fibrillation and stroke: Analysis via the support vector machine neural network. | 2 |
| 33227819 | 2021 | A natural DNMT1 mutation elevates the fetal hemoglobin level via epigenetic derepression of the γ-globin gene in β-thalassemia. | 15 |
| 33649594 | 2021 | Transcription factor competition at the γ-globin promoters controls hemoglobin switching. | 33 |
| 33744764 | 2021 | Long noncoding RNA HBBP1 enhances γ-globin expression through the ETS transcription factor ELK1. | 5 |
| 34341563 | 2021 | Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin. | 19 |
| 34406845 | 2021 | Drug Repurposing: Hydroxyurea Therapy Improves the Transfusion-Free Interval in HbE/Beta-Thalassemia-Major Patients with the XmnI Polymorphism. | 3 |
| 34535703 | 2021 | Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals. | 4 |
| 34569056 | 2021 | TEA domain transcription factor 4 modulates repression of fetal haemoglobin by direct binding to the γ-globin gene promoters. | 0 |
| 33227819 | 2021 | A natural DNMT1 mutation elevates the fetal hemoglobin level via epigenetic derepression of the γ-globin gene in β-thalassemia. | 15 |
| 33649594 | 2021 | Transcription factor competition at the γ-globin promoters controls hemoglobin switching. | 33 |
| 33744764 | 2021 | Long noncoding RNA HBBP1 enhances γ-globin expression through the ETS transcription factor ELK1. | 5 |
| 34341563 | 2021 | Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin. | 19 |
Citation
Dessen P
HBG1 (hemoglobin subunit gamma 1)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56256/hbg1-(hemoglobin-subunit-gamma-1)
