Identity
HGNC
LOCATION
2p23.3
LOCUSID
ALIAS
K2p3.1,OAT1,PPH4,TASK,TASK-1,TASK1,TBAK1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3777
MIM: 603220
HGNC: 6278
Ensembl: ENSG00000171303
Variants:
dbSNP: 3777
ClinVar: 3777
TCGA: ENSG00000171303
COSMIC: KCNK3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000171303 | ENST00000302909 | O14649 |
| ENSG00000171303 | ENST00000620977 | B9EIJ4 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 31327267 | |
| PA448765 | candesartan | Chemical | ClinicalAnnotation | associated | PD | 31327267 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37793594 | 2023 | Activation of neurokinin-III receptors modulates human atrial TASK-1 currents. | 0 |
| 37793594 | 2023 | Activation of neurokinin-III receptors modulates human atrial TASK-1 currents. | 0 |
| 35301863 | 2022 | MicroRNAs Regulate TASK-1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation. | 10 |
| 36016502 | 2022 | Crosstalk between BMP signaling and KCNK3 in phenotypic switching of pulmonary vascular smooth muscle cells. | 3 |
| 36195757 | 2022 | Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea. | 6 |
| 35301863 | 2022 | MicroRNAs Regulate TASK-1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation. | 10 |
| 36016502 | 2022 | Crosstalk between BMP signaling and KCNK3 in phenotypic switching of pulmonary vascular smooth muscle cells. | 3 |
| 36195757 | 2022 | Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea. | 6 |
| 34038243 | 2021 | Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH. | 4 |
| 34065088 | 2021 | KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models. | 9 |
| 34571371 | 2021 | TASK-1 regulates mitochondrial function under hypoxia. | 1 |
| 35011589 | 2021 | Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors. | 3 |
| 34038243 | 2021 | Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH. | 4 |
| 34065088 | 2021 | KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models. | 9 |
| 34571371 | 2021 | TASK-1 regulates mitochondrial function under hypoxia. | 1 |
Citation
Dessen P
KCNK3 (potassium two pore domain channel subfamily K member 3)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56262/gene-explorer/case-report-explorer/
