STX8 (syntaxin 8)

2016-10-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
CARB
FUSION GENES

Other Information

Locus ID:

NCBI: 9482
MIM: 604203
HGNC: 11443
Ensembl: ENSG00000170310

Variants:

dbSNP: 9482
ClinVar: 9482
TCGA: ENSG00000170310
COSMIC: STX8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170310ENST00000306357Q9UNK0
ENSG00000170310ENST00000573016I3L305
ENSG00000170310ENST00000574431K7EQB1
ENSG00000170310ENST00000575294K7ER37
ENSG00000170310ENST00000575858I3L3D0

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191747802009Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.52
194229352009Genetic risk profiling and prediction of disease course in Crohn's disease patients.33
149918452004Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease.25
150394622004Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity.15
185709182008Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells.13
189809422009Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8.13
208860652010Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.11
246597812014Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.11
254047412015Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability.9

Citation

Dessen P

STX8 (syntaxin 8)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56267/stx8-(syntaxin-8)