PILRA (paired immunoglobin like type 2 receptor alpha)

2016-10-01  

Identity

HGNC
PILRA
LOCATION
7q22.1
LOCUSID
29992
ALIAS
FDF03
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29992
MIM: 605341
HGNC: 20396
Ensembl: ENSG00000085514

Variants:

dbSNP: 29992
ClinVar: 29992
TCGA: ENSG00000085514
COSMIC: PILRA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085514ENST00000198536Q9UKJ1
ENSG00000085514ENST00000350573Q9UKJ1
ENSG00000085514ENST00000394000Q9UKJ1
ENSG00000085514ENST00000432297C9JGG1
ENSG00000085514ENST00000453419C9JJ79

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384081132024New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes.0
384081132024New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes.0
356174012022The CD8α-PILRα interaction maintains CD8(+) T cell quiescence.8
359184472022PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk.3
356174012022The CD8α-PILRα interaction maintains CD8(+) T cell quiescence.8
359184472022PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk.3
346024892021Inhibitory Fcγ Receptor and Paired Immunoglobulin Type 2 Receptor Alpha Genotypes in Alzheimer's Disease.0
346024892021Inhibitory Fcγ Receptor and Paired Immunoglobulin Type 2 Receptor Alpha Genotypes in Alzheimer's Disease.0
312976372019The PILRA G78R Variant Correlates with Higher HSV-1-Specific IgG Titers in Alzheimer's Disease.9
312976372019The PILRA G78R Variant Correlates with Higher HSV-1-Specific IgG Titers in Alzheimer's Disease.9
291818572018Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease.19
303881012018Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease.35
291818572018Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease.19
303881012018Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease.35
290463572017Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRα immune cell receptor.4

Citation

Dessen P

PILRA (paired immunoglobin like type 2 receptor alpha)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56280/pilra-(paired-immunoglobin-like-type-2-receptor-alpha)