SLC3A1 (solute carrier family 3 member 1)

2016-10-01  

Identity

HGNC
LOCATION
2p21
LOCUSID
ALIAS
ATR1,CSNU1,D2H,NBAT,RBAT
FUSION GENES

Other Information

Locus ID:

NCBI: 6519
MIM: 104614
HGNC: 11025
Ensembl: ENSG00000138079

Variants:

dbSNP: 6519
ClinVar: 6519
TCGA: ENSG00000138079
COSMIC: SLC3A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138079ENST00000260649Q07837
ENSG00000138079ENST00000260649A0A0S2Z4E1
ENSG00000138079ENST00000409229Q07837
ENSG00000138079ENST00000409294B8ZZP2
ENSG00000138079ENST00000409380Q07837
ENSG00000138079ENST00000409387B8ZZK1
ENSG00000138079ENST00000409740Q07837
ENSG00000138079ENST00000409741Q07837
ENSG00000138079ENST00000410056Q07837
ENSG00000138079ENST00000427285C9JBK3
ENSG00000138079ENST00000611973A0A087X0R9

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
374398392023Interpretation of SLC3A1 and SLC7A9 variants in cystinuria patients: The significance of the PM3 criterion and protein stability.1
375612002023Population genetics analysis of SLC3A1 and SLC7A9 revealed the etiology of cystine stone may be more than what our current genetic knowledge can explain.2
381149972023Novel compound heterozygous pathogenic variants in the SLC3A1 gene in a Chinese family with cystinuria.0
374398392023Interpretation of SLC3A1 and SLC7A9 variants in cystinuria patients: The significance of the PM3 criterion and protein stability.1
375612002023Population genetics analysis of SLC3A1 and SLC7A9 revealed the etiology of cystine stone may be more than what our current genetic knowledge can explain.2
381149972023Novel compound heterozygous pathogenic variants in the SLC3A1 gene in a Chinese family with cystinuria.0
333491022021Clinical profile of a Polish cohort of children and young adults with cystinuria.2
333491022021Clinical profile of a Polish cohort of children and young adults with cystinuria.2
328175652020Structural basis for amino acid exchange by a human heteromeric amino acid transporter.13
328175652020Structural basis for amino acid exchange by a human heteromeric amino acid transporter.13
300698162018In silico analysis of SLC3A1 and SLC7A9 mutations in Iranian patients with Cystinuria.4
301468432018Clinical, Biochemical, and Genetic Findings of Cystinuria in Chinese Children.4
300698162018In silico analysis of SLC3A1 and SLC7A9 mutations in Iranian patients with Cystinuria.4
301468432018Clinical, Biochemical, and Genetic Findings of Cystinuria in Chinese Children.4
281667402017Delineation of cystinuria in Saudi Arabia: A case series.3

Citation

Dessen P

SLC3A1 (solute carrier family 3 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56285/slc3a1-(solute-carrier-family-3-member-1)