CHRM4 (cholinergic receptor muscarinic 4)

2016-10-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
HM4,M4R

Other Information

Locus ID:

NCBI: 1132
MIM: 118495
HGNC: 1953
Ensembl: ENSG00000180720

Variants:

dbSNP: 1132
ClinVar: 1132
TCGA: ENSG00000180720
COSMIC: CHRM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180720ENST00000433765P08173

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Regulation of actin cytoskeletonKEGGko04810
Neuroactive ligand-receptor interactionKEGGhsa04080
Regulation of actin cytoskeletonKEGGhsa04810
Cholinergic synapseKEGGhsa04725
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Muscarinic acetylcholine receptorsREACTOMER-HSA-390648
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
348066122022Muscarinic Receptors Expression in the Peripheral Blood Cells Differentiate Dementia with Lewy Bodies from Alzheimer's Disease.3
348066122022Muscarinic Receptors Expression in the Peripheral Blood Cells Differentiate Dementia with Lewy Bodies from Alzheimer's Disease.3
322343872020Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway.2
322343872020Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway.2
312114712019Roles of the M(4) acetylcholine receptor in the basal ganglia and the treatment of movement disorders.18
312114712019Roles of the M(4) acetylcholine receptor in the basal ganglia and the treatment of movement disorders.18
269588382016Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.148
272699052016African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction.4
269588382016Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.148
272699052016African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction.4
260250562015Modified expression of peripheral blood lymphocyte muscarinic cholinergic receptors in asthmatic children.1
260250562015Modified expression of peripheral blood lymphocyte muscarinic cholinergic receptors in asthmatic children.1
247683002014Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior.216
248079662014Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites.12
247683002014Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior.216

Citation

Dessen P

CHRM4 (cholinergic receptor muscarinic 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56289/chrm4-(cholinergic-receptor-muscarinic-4)