CEP131 (centrosomal protein 131)

2016-10-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
AZ1,AZI1,ZA1
FUSION GENES

Other Information

Locus ID:

NCBI: 22994
MIM: 613479
HGNC: 29511
Ensembl: ENSG00000141577

Variants:

dbSNP: 22994
ClinVar: 22994
TCGA: ENSG00000141577
COSMIC: CEP131

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141577ENST00000269392Q9UPN4
ENSG00000141577ENST00000374782Q9UPN4
ENSG00000141577ENST00000450824Q9UPN4
ENSG00000141577ENST00000570817I3L4M5
ENSG00000141577ENST00000571292I3L316
ENSG00000141577ENST00000573053I3L2X7
ENSG00000141577ENST00000575907I3L2J8

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
360083832022Hepatic ARID3A facilitates liver cancer malignancy by cooperating with CEP131 to regulate an embryonic stem cell-like gene signature.4
360083832022Hepatic ARID3A facilitates liver cancer malignancy by cooperating with CEP131 to regulate an embryonic stem cell-like gene signature.4
308042082019Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131).12
313587342019Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability.17
308042082019Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131).12
313587342019Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability.17
305381952018RNA-mediated gene fusion in mammalian cells.15
305381952018RNA-mediated gene fusion in mammalian cells.15
286941052017CEP131 indicates poor prognosis and promotes cell proliferation and migration in hepatocellular carcinoma.14
286941052017CEP131 indicates poor prognosis and promotes cell proliferation and migration in hepatocellular carcinoma.14
266167342015p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1.31
266167342015p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1.31
231376372013Regulation of CEP131 gene expression by SP1.3
231376372013Regulation of CEP131 gene expression by SP1.3
227979152012The centriolar satellite protein Cep131 is important for genome stability.69

Citation

Dessen P

CEP131 (centrosomal protein 131)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56290/cep131-(centrosomal-protein-131)