SLAMF6 (SLAM family member 6)

2016-10-01  

Identity

HGNC
SLAMF6
LOCATION
1q23.2
LOCUSID
114836
ALIAS
CD352,KALI,KALIb,Ly108,NTB-A,NTBA,SF2000

Other Information

Locus ID:

NCBI: 114836
MIM: 606446
HGNC: 21392
Ensembl: ENSG00000162739

Variants:

dbSNP: 114836
ClinVar: 114836
TCGA: ENSG00000162739
COSMIC: SLAMF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162739ENST00000368055Q96DU3
ENSG00000162739ENST00000368057Q96DU3
ENSG00000162739ENST00000368059Q96DU3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382870612024Clinical and immunological relevance of SLAMF6 expression in the tumor microenvironment of breast cancer and melanoma.1
382870612024Clinical and immunological relevance of SLAMF6 expression in the tumor microenvironment of breast cancer and melanoma.1
350167292022SLAMF6 is associated with the susceptibility and severity of rheumatoid arthritis in the Chinese population.2
350167292022SLAMF6 is associated with the susceptibility and severity of rheumatoid arthritis in the Chinese population.2
337745562021Expression and function of SLAMF6 in CD8(+) T lymphocytes of patients with severe aplastic anemia.2
337745562021Expression and function of SLAMF6 in CD8(+) T lymphocytes of patients with severe aplastic anemia.2
311998202019SLAMF6 clustering is required to augment T cell activation.17
311998202019SLAMF6 clustering is required to augment T cell activation.17
293055202018Soluble SLAMF6 Receptor Induces Strong CD8(+) T-cell Effector Function and Improves Anti-Melanoma Activity In Vivo.12
293055202018Soluble SLAMF6 Receptor Induces Strong CD8(+) T-cell Effector Function and Improves Anti-Melanoma Activity In Vivo.12
283735842017Invariant NKT Cell Activation Is Potentiated by Homotypic trans-Ly108 Interactions.5
285465492017Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses.4
283735842017Invariant NKT Cell Activation Is Potentiated by Homotypic trans-Ly108 Interactions.5
285465492017Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses.4
268781122016A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.32

Citation

Dessen P

SLAMF6 (SLAM family member 6)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56305/slamf6-(slam-family-member-6)