Identity
HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
IZUMO,OBF
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 284359
MIM: 609278
HGNC: 28539
Ensembl: ENSG00000182264
Variants:
dbSNP: 284359
ClinVar: 284359
TCGA: ENSG00000182264
COSMIC: IZUMO1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000182264 | ENST00000332955 | Q8IYV9 |
| ENSG00000182264 | ENST00000595517 | Q8IYV9 |
| ENSG00000182264 | ENST00000595937 | Q8IYV9 |
| ENSG00000182264 | ENST00000602105 | M0R0B8 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Reproduction | REACTOME | R-HSA-1474165 |
| Fertilization | REACTOME | R-HSA-1187000 |
| Sperm:Oocyte Membrane Binding | REACTOME | R-HSA-1300652 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38381819 | 2024 | No evidence for a direct extracellular interaction between human Fc receptor-like 3 (MAIA) and the sperm ligand IZUMO1. | 1 |
| 38381819 | 2024 | No evidence for a direct extracellular interaction between human Fc receptor-like 3 (MAIA) and the sperm ligand IZUMO1. | 1 |
| 34879103 | 2021 | Genetic diversity in the IZUMO1-JUNO protein-receptor pair involved in human reproduction. | 1 |
| 34879103 | 2021 | Genetic diversity in the IZUMO1-JUNO protein-receptor pair involved in human reproduction. | 1 |
| 27309808 | 2016 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization. | 66 |
| 27309818 | 2016 | Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex. | 61 |
| 27309808 | 2016 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization. | 66 |
| 27309818 | 2016 | Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex. | 61 |
| 23279005 | 2013 | Presence and incidence of izumo antibodies in sera of immunoinfertile women and men. | 10 |
| 23279005 | 2013 | Presence and incidence of izumo antibodies in sera of immunoinfertile women and men. | 10 |
| 18082733 | 2008 | Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure. | 2 |
| 18082733 | 2008 | Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure. | 2 |
| 18082733 | 2008 | Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure. | 2 |
| 18082733 | 2008 | Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure. | 2 |
| 15759005 | 2005 | The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. | 277 |
Citation
Dessen P
IZUMO1 (izumo sperm-egg fusion 1)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56314/chromosome-explorer/gene-explorer/
