LPIN2 (lipin 2)

Identity

HGNC

LPIN2

LOCATION

18p11.31

LOCUSID

9663

ALIAS

-

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 9663
MIM: 605519
HGNC: 14450
Ensembl: ENSG00000101577

Variants:

dbSNP: 9663
ClinVar: 9663
TCGA: ENSG00000101577
COSMIC: LPIN2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000101577	ENST00000261596	Q92539
ENSG00000101577	ENST00000584294	J3KTK1
ENSG00000101577	ENST00000584915	J3QQN0

Expression (GTEx)

0

5

10

15

20

25

30

35

40

45

50

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycerolipid metabolism	KEGG	ko00561
Glycerophospholipid metabolism	KEGG	ko00564
Glycerolipid metabolism	KEGG	hsa00561
Glycerophospholipid metabolism	KEGG	hsa00564
Metabolic pathways	KEGG	hsa01100
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Nuclear Envelope Breakdown	REACTOME	R-HSA-2980766
Depolymerisation of the Nuclear Lamina	REACTOME	R-HSA-4419969
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Triglyceride Biosynthesis	REACTOME	R-HSA-75109
Phospholipid metabolism	REACTOME	R-HSA-1483257
Glycerophospholipid biosynthesis	REACTOME	R-HSA-1483206
Synthesis of PE	REACTOME	R-HSA-1483213
Synthesis of PC	REACTOME	R-HSA-1483191

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15994876	2005	Homozygous mutations in LPIN2 are responsible for the syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia (Majeed syndrome).	100
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
19717560	2009	A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.	61
18694939	2008	Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.	58
23087183	2013	Efficacy of anti-IL-1 treatment in Majeed syndrome.	51
19136718	2009	Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.	38
22481384	2012	Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia.	25
17804763	2007	LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition.	24
17804763	2007	LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition.	24
22334674	2012	Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages.	24

Citation

Dessen P

LPIN2 (lipin 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56317/lpin2-(lipin-2)