HOOK1 (hook microtubule tethering protein 1)

2016-10-01  

Identity

HGNC
HOOK1
LOCATION
1p32.1
LOCUSID
51361
ALIAS
HK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51361
MIM: 607820
HGNC: 19884
Ensembl: ENSG00000134709

Variants:

dbSNP: 51361
ClinVar: 51361
TCGA: ENSG00000134709
COSMIC: HOOK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134709ENST00000371208Q9UJC3
ENSG00000134709ENST00000455990B1AK95

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
235894922013Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1.59
154718872004Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway.55
187996222008An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.43
273654012016Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction.37
253319522014SHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.15
287183702017Hook1 inhibits malignancy and epithelial-mesenchymal transition in hepatocellular carcinoma.3
293303342018Detection of heterozygous mutation in hook microtubule-tethering protein 1 in three patients with decapitated and decaudated spermatozoa syndrome.3
299538942018Clinicopathological and prognostic significance of SHP2 and Hook1 expression in patients with thyroid carcinoma.2

Citation

Dessen P

HOOK1 (hook microtubule tethering protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56325/hook1-(hook-microtubule-tethering-protein-1)