NDEL1 (nudE neurodevelopment protein 1 like 1)

2016-10-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
EOPA,MITAP1,NDE1L1,NDE2,NUDEL
FUSION GENES

Other Information

Locus ID:

NCBI: 81565
MIM: 607538
HGNC: 17620
Ensembl: ENSG00000166579

Variants:

dbSNP: 81565
ClinVar: 81565
TCGA: ENSG00000166579
COSMIC: NDEL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166579ENST00000334527Q9GZM8
ENSG00000166579ENST00000380025A6NIZ0
ENSG00000166579ENST00000402554Q9GZM8
ENSG00000166579ENST00000580012J3QL31
ENSG00000166579ENST00000580237J3QRD2
ENSG00000166579ENST00000581679J3QSD2
ENSG00000166579ENST00000582277J3QRZ1
ENSG00000166579ENST00000582490J3KT16
ENSG00000166579ENST00000582665J3QL85
ENSG00000166579ENST00000582812J3KRK9
ENSG00000166579ENST00000584866J3KSF2
ENSG00000166579ENST00000585098J3QLD0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381940502024Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations.0
381940502024Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations.0
368586062023Effects of representative point mutations on dynamic behavior of the DISC1-Ndel1 complex: a molecular dynamics study.0
370867892023Ndel1 disfavors dynein-dynactin-adaptor complex formation in two distinct ways.8
368586062023Effects of representative point mutations on dynamic behavior of the DISC1-Ndel1 complex: a molecular dynamics study.0
370867892023Ndel1 disfavors dynein-dynactin-adaptor complex formation in two distinct ways.8
303217662019Oligopeptidases activity in bipolar disorder: Ndel1 and angiotensin I converting enzyme.3
318156652019Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis.17
303217662019Oligopeptidases activity in bipolar disorder: Ndel1 and angiotensin I converting enzyme.3
318156652019Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis.17
273717632017Developmental Alcohol Exposure Impairs Activity-Dependent S-Nitrosylation of NDEL1 for Neuronal Maturation.6
291038082017DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis.73
273717632017Developmental Alcohol Exposure Impairs Activity-Dependent S-Nitrosylation of NDEL1 for Neuronal Maturation.6
291038082017DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis.73
268511412016Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity.8

Citation

Dessen P

NDEL1 (nudE neurodevelopment protein 1 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56336/ndel1-(nude-neurodevelopment-protein-1-like-1)