KIFAP3 (kinesin associated protein 3)

2016-10-01  

Identity

HGNC
KIFAP3
LOCATION
1q24.2
LOCUSID
22920
ALIAS
FLA3,KAP-1,KAP-3,KAP3,SMAP,Smg-GDS,dJ190I16.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22920
MIM: 601836
HGNC: 17060
Ensembl: ENSG00000075945

Variants:

dbSNP: 22920
ClinVar: 22920
TCGA: ENSG00000075945
COSMIC: KIFAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075945ENST00000361580Q92845
ENSG00000075945ENST00000367765Q92845
ENSG00000075945ENST00000367767Q92845
ENSG00000075945ENST00000538366Q92845

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Intraflagellar transportREACTOMER-HSA-5620924
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380132232024Novel regulatory roles of small G protein GDP dissociation stimulator (smgGDS) in insulin secretion from pancreatic β-cells.1
388697182024LncRNA KIFAP3-5:1 inhibits epithelial-mesenchymal transition of renal tubular cell through PRRX1 in diabetic nephropathy.0
380132232024Novel regulatory roles of small G protein GDP dissociation stimulator (smgGDS) in insulin secretion from pancreatic β-cells.1
388697182024LncRNA KIFAP3-5:1 inhibits epithelial-mesenchymal transition of renal tubular cell through PRRX1 in diabetic nephropathy.0
353220782022Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach.1
353220782022Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach.1
346747292021Novel alterations in IFT172 and KIFAP3 may induce basal cell carcinoma.1
346747292021Novel alterations in IFT172 and KIFAP3 may induce basal cell carcinoma.1
327858702020Analysis of KAP1 expression patterns and human endogenous retrovirus Env proteins in ovarian cancer.6
327858702020Analysis of KAP1 expression patterns and human endogenous retrovirus Env proteins in ovarian cancer.6
281406762017Further analysis of KIFAP3 gene in ALS patients from Switzerland and Sweden.2
281406762017Further analysis of KIFAP3 gene in ALS patients from Switzerland and Sweden.2
255888312015The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.28
255888312015The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.28
248381852014Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study.9

Citation

Dessen P

KIFAP3 (kinesin associated protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56347/teaching-explorer/hgnc