CSTF3 (cleavage stimulation factor subunit 3)

2016-10-01 Affiliation

Identity

HGNC

CSTF3

LOCATION

11p13

LOCUSID

1479

ALIAS

CSTF-77

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1479
MIM: 600367
HGNC: 2485
Ensembl: ENSG00000176102

Variants:

dbSNP: 1479
ClinVar: 1479
TCGA: ENSG00000176102
COSMIC: CSTF3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000176102	ENST00000323959	Q12996
ENSG00000176102	ENST00000431742	Q12996
ENSG00000176102	ENST00000438862	Q12996
ENSG00000176102	ENST00000524556	E9PNK2
ENSG00000176102	ENST00000524775	E9PJ06
ENSG00000176102	ENST00000524827	E9PLP8
ENSG00000176102	ENST00000528865	H0YE74

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
mRNA surveillance pathway	KEGG	ko03015
mRNA surveillance pathway	KEGG	hsa03015
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Transcription Termination	REACTOME	R-HSA-73856
Cleavage of Growing Transcript in the Termination Region	REACTOME	R-HSA-109688
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA Splicing	REACTOME	R-HSA-72172
mRNA Splicing - Major Pathway	REACTOME	R-HSA-72163
mRNA 3'-end processing	REACTOME	R-HSA-72187
Processing of Capped Intronless Pre-mRNA	REACTOME	R-HSA-75067
Processing of Intronless Pre-mRNAs	REACTOME	R-HSA-77595

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21119002	2011	Interactions of CstF-64, CstF-77, and symplekin: implications on localisation and function.	33
23874216	2013	The conserved intronic cleavage and polyadenylation site of CstF-77 gene imparts control of 3' end processing activity through feedback autoregulation and by U1 snRNP.	21
26288249	2015	Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.	17
19887456	2010	The hinge domain of the cleavage stimulation factor protein CstF-64 is essential for CstF-77 interaction, nuclear localization, and polyadenylation.	14
12149458	2002	Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila.	9
29186539	2018	Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3'-end processing signals.	4
30257008	2018	The structural basis of CstF-77 modulation of cleavage and polyadenylation through stimulation of CstF-64 activity.	1

Citation

Dessen P

CSTF3 (cleavage stimulation factor subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56349/cstf3-(cleavage-stimulation-factor-subunit-3)