CCNL2 (cyclin L2)

2016-10-01  

Identity

HGNC
CCNL2
LOCATION
1p36.33
LOCUSID
81669
ALIAS
ANIA-6B,CCNM,CCNS,HCLA-ISO,HLA-ISO,PCEE,SB138
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81669
MIM: 613482
HGNC: 20570
Ensembl: ENSG00000221978

Variants:

dbSNP: 81669
ClinVar: 81669
TCGA: ENSG00000221978
COSMIC: CCNL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000221978ENST00000400809Q96S94
ENSG00000221978ENST00000408918Q96S94
ENSG00000221978ENST00000408952A0A0A0MSF3
ENSG00000221978ENST00000425598C9J148
ENSG00000221978ENST00000481223Q96S94
ENSG00000221978ENST00000482621J3KRL1
ENSG00000221978ENST00000488340Q96S94
ENSG00000221978ENST00000497013J3QSH2

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
182160182008Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.45
146238752004Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.35
146847362004Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells.31
255328052015Cyclin L2 is a critical HIV dependency factor in macrophages that controls SAMHD1 abundance.26
242185722013CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.25
174949912007Characterization of cyclin L1 as an immobile component of the splicing factor compartment.8

Citation

Dessen P

CCNL2 (cyclin L2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56362/ccnl2-(cyclin-l2)