TBC1D2B (TBC1 domain family member 2B)

2016-10-01  

Identity

HGNC
LOCATION
15q24.3
LOCUSID
ALIAS
NEDSGO
FUSION GENES

Other Information

Locus ID:

NCBI: 23102
HGNC: 29183
Ensembl: ENSG00000167202

Variants:

dbSNP: 23102
ClinVar: 23102
TCGA: ENSG00000167202
COSMIC: TBC1D2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167202ENST00000300584Q9UPU7
ENSG00000167202ENST00000409931Q9UPU7
ENSG00000167202ENST00000435468C9JW56
ENSG00000167202ENST00000465531H0YL97

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
360291302022Biallelic frameshift variant in the TBC1D2B gene in two siblings with progressive gingival overgrowth, fibrous dysplasia of face, and mental deterioration.1
360291302022Biallelic frameshift variant in the TBC1D2B gene in two siblings with progressive gingival overgrowth, fibrous dysplasia of face, and mental deterioration.1
326237942020Biallelic loss-of-function variants in TBC1D2B cause a neurodevelopmental disorder with seizures and gingival overgrowth.5
326237942020Biallelic loss-of-function variants in TBC1D2B cause a neurodevelopmental disorder with seizures and gingival overgrowth.5
317195312019ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer.50
317195312019ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer.50
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

TBC1D2B (TBC1 domain family member 2B)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56364/tumors-explorer/gene-explorer/