SLC7A2 (solute carrier family 7 member 2)

2016-10-01  

Identity

HGNC
LOCATION
8p22
LOCUSID
ALIAS
ATRC2,CAT2,HCAT2
FUSION GENES

Other Information

Locus ID:

NCBI: 6542
MIM: 601872
HGNC: 11060
Ensembl: ENSG00000003989

Variants:

dbSNP: 6542
ClinVar: 6542
TCGA: ENSG00000003989
COSMIC: SLC7A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000003989ENST00000004531P52569
ENSG00000003989ENST00000398090P52569
ENSG00000003989ENST00000470360P52569
ENSG00000003989ENST00000494857P52569
ENSG00000003989ENST00000522656P52569
ENSG00000003989ENST00000640220A0A1W2PR06

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

References

Pubmed IDYearTitleCitations
384190382024Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease.0
388422022024SLC7A2-Mediated Lysine Catabolism Inhibits Immunosuppression in Triple Negative Breast Cancer.0
384190382024Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease.0
388422022024SLC7A2-Mediated Lysine Catabolism Inhibits Immunosuppression in Triple Negative Breast Cancer.0
366397712023Lower SLC7A2 expression is associated with enhanced multidrug resistance, less immune infiltrates and worse prognosis of NSCLC.4
382032682023Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation.0
366397712023Lower SLC7A2 expression is associated with enhanced multidrug resistance, less immune infiltrates and worse prognosis of NSCLC.4
382032682023Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation.0
341084442021SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells.17
341084442021SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells.17
320080932020Human cationic amino acid transporters are not affected by direct nitros(yl)ation.1
326470702020SLC7A2 serves as a potential biomarker and therapeutic target for ovarian cancer.15
320080932020Human cationic amino acid transporters are not affected by direct nitros(yl)ation.1
326470702020SLC7A2 serves as a potential biomarker and therapeutic target for ovarian cancer.15
285017042017Genetic variation in SLC7A2 interacts with calcium and magnesium intakes in modulating the risk of colorectal polyps.5

Citation

Dessen P

SLC7A2 (solute carrier family 7 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56383/slc7a2-(solute-carrier-family-7-member-2)