CPA1 (carboxypeptidase A1)

2016-10-01  

Identity

HGNC
LOCATION
7q32.2
LOCUSID
ALIAS
CPA
FUSION GENES

Other Information

Locus ID:

NCBI: 1357
MIM: 114850
HGNC: 2296
Ensembl: ENSG00000091704

Variants:

dbSNP: 1357
ClinVar: 1357
TCGA: ENSG00000091704
COSMIC: CPA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091704ENST00000011292P15085
ENSG00000091704ENST00000476062C9JUZ4
ENSG00000091704ENST00000481342C9JQ63
ENSG00000091704ENST00000484324C9JUF9
ENSG00000091704ENST00000604896S4R433

Expression (GTEx)

0
10000
20000
30000
40000
50000
60000

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
273584032016Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.8
296699192018Mutations in the pancreatic secretory enzymes <i>CPA1</i> and <i>CPB1</i> are associated with pancreatic cancer.8
185665132008Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid).6
274090672016Genetic Analysis of Japanese Children With Acute Recurrent and Chronic Pancreatitis.6
284975642017No significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort.4
215021832012Serum procarboxypeptidase A and carboxypeptidase A levels in pancreatic disease.3
239555962013Variants in CPA1 are strongly associated with early onset chronic pancreatitis.0

Citation

Dessen P

CPA1 (carboxypeptidase A1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56385/cpa1-(carboxypeptidase-a1)