NUDT9 (nudix hydrolase 9)

2016-10-01  

Identity

HGNC
LOCATION
4q22.1
LOCUSID
ALIAS
NUDT10

Other Information

Locus ID:

NCBI: 53343
MIM: 606022
HGNC: 8056
Ensembl: ENSG00000170502

Variants:

dbSNP: 53343
ClinVar: 53343
TCGA: ENSG00000170502
COSMIC: NUDT9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170502ENST00000302174Q9BW91
ENSG00000170502ENST00000302174A0A024RDI6
ENSG00000170502ENST00000440591H7C386
ENSG00000170502ENST00000473942Q9BW91
ENSG00000170502ENST00000502933D6R8Z6
ENSG00000170502ENST00000512216D6RAW2

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Phosphate bond hydrolysis by NUDT proteinsREACTOMER-HSA-2393930

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373437112023NUDT6 and NUDT9, two mitochondrial members of the NUDIX family, have distinct hydrolysis activities.0
373437112023NUDT6 and NUDT9, two mitochondrial members of the NUDIX family, have distinct hydrolysis activities.0
341898462021Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9.1
341898462021Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9.1
301901332018The ADP-ribose reactive NUDIX hydrolase isoforms can modulate HIF-1α in cancer cells.3
301901332018The ADP-ribose reactive NUDIX hydrolase isoforms can modulate HIF-1α in cancer cells.3
195741672009Differential expression of NUDT9 at different phases of the menstrual cycle and in different components of normal and neoplastic human endometrium.2
195741672009Differential expression of NUDT9 at different phases of the menstrual cycle and in different components of normal and neoplastic human endometrium.2
168604842006The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.6
168604842006The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.6
124277522003NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase.52
129484892003The crystal structure and mutational analysis of human NUDT9.40
124277522003NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase.52
129484892003The crystal structure and mutational analysis of human NUDT9.40
118256152002Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose).13

Citation

Dessen P

NUDT9 (nudix hydrolase 9)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56389/case-report-explorer/gene-explorer/