GCC1 (GRIP and coiled-coil domain containing 1)

2016-10-01  

Identity

HGNC
LOCATION
7q32.1
LOCUSID
ALIAS
GCC1P,GCC88

Other Information

Locus ID:

NCBI: 79571
MIM: 607418
HGNC: 19095
Ensembl: ENSG00000179562

Variants:

dbSNP: 79571
ClinVar: 79571
TCGA: ENSG00000179562
COSMIC: GCC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179562ENST00000321407Q96CN9
ENSG00000179562ENST00000321407A4D0Z4

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
342447812021Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.5
342447812021Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.5
332396402020Spatial proteomics defines the content of trafficking vesicles captured by golgin tethers.35
332396402020Spatial proteomics defines the content of trafficking vesicles captured by golgin tethers.35
305405232019Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture.18
307911782019A role of GCC88 in the retrograde transport of CI-M6PR and the maintenance of lysosomal activity.1
305405232019Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture.18
307911782019A role of GCC88 in the retrograde transport of CI-M6PR and the maintenance of lysosomal activity.1
179140562007The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network.35
179140562007The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network.35
156547692005The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.13
156547692005The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.13
124466652003GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network.55
124466652003GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network.55

Citation

Dessen P

GCC1 (GRIP and coiled-coil domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56391/gcc1-(grip-and-coiled-coil-domain-containing-1)