IFNA4 (interferon alpha 4)

2016-10-01 Affiliation

Identity

HGNC

IFNA4

LOCATION

9p21.3

LOCUSID

3441

ALIAS

IFN-alpha4a,INFA4

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3441
MIM: 147564
HGNC: 5425
Ensembl: ENSG00000236637

Variants:

dbSNP: 3441
ClinVar: 3441
TCGA: ENSG00000236637
COSMIC: IFNA4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000236637	ENST00000421715	P05014

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Toll-like receptor signaling pathway	KEGG	ko04620
Jak-STAT signaling pathway	KEGG	ko04630
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Autoimmune thyroid disease	KEGG	ko05320
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Toll-like receptor signaling pathway	KEGG	hsa04620
Jak-STAT signaling pathway	KEGG	hsa04630
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Autoimmune thyroid disease	KEGG	hsa05320
RIG-I-like receptor signaling pathway	KEGG	ko04622
RIG-I-like receptor signaling pathway	KEGG	hsa04622
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Cytosolic DNA-sensing pathway	KEGG	ko04623
Cytosolic DNA-sensing pathway	KEGG	hsa04623
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Hepatitis B	KEGG	hsa05161
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
TRAF6 mediated IRF7 activation	REACTOME	R-HSA-933541
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon alpha/beta signaling	REACTOME	R-HSA-909733
Regulation of IFNA signaling	REACTOME	R-HSA-912694
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
32111355	2020	The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene.	3
32111355	2020	The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene.	3
26000985	2015	Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients.	2
26000985	2015	Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients.	2
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	37
20588308	2010	Dengue hemorrhagic fever is associated with polymorphisms in JAK1.	12
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	37
20588308	2010	Dengue hemorrhagic fever is associated with polymorphisms in JAK1.	12
15163721	2004	Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.	75
15163721	2004	Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.	75
8668211	1996	Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.	21
8668211	1996	Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.	21

Citation

Dessen P

IFNA4 (interferon alpha 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56418/teaching-explorer/

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