Identity
HGNC
LOCATION
17p13.3
LOCUSID
ALIAS
C17orf31,EST1A,SMG-6,hSMG5/7a
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23293
MIM: 610963
HGNC: 17809
Ensembl: ENSG00000070366
Variants:
dbSNP: 23293
ClinVar: 23293
TCGA: ENSG00000070366
COSMIC: SMG6
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38709891 | 2024 | UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2. | 0 |
| 38709891 | 2024 | UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2. | 0 |
| 35487895 | 2022 | CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway. | 11 |
| 35487895 | 2022 | CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway. | 11 |
| 32941650 | 2020 | Readthrough of stop codons under limiting ABCE1 concentration involves frameshifting and inhibits nonsense-mediated mRNA decay. | 17 |
| 32941650 | 2020 | Readthrough of stop codons under limiting ABCE1 concentration involves frameshifting and inhibits nonsense-mediated mRNA decay. | 17 |
| 29363864 | 2018 | SRR intronic variation inhibits expression of its neighbouring SMG6 gene and protects against temporal lobe epilepsy. | 3 |
| 29363864 | 2018 | SRR intronic variation inhibits expression of its neighbouring SMG6 gene and protects against temporal lobe epilepsy. | 3 |
| 27864472 | 2017 | Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways. | 104 |
| 28461625 | 2017 | Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates. | 20 |
| 27864472 | 2017 | Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways. | 104 |
| 28461625 | 2017 | Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates. | 20 |
| 25429978 | 2015 | Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. | 58 |
| 25429978 | 2015 | Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. | 58 |
| 25013172 | 2014 | Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6. | 63 |
Citation
Dessen P
SMG6 (SMG6 nonsense mediated mRNA decay factor)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56420/smg6-(smg6-nonsense-mediated-mrna-decay-factor)
