Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 125170
MIM: 615498
HGNC: 17920
Ensembl: ENSG00000177427
Variants:
dbSNP: 125170
ClinVar: 125170
TCGA: ENSG00000177427
COSMIC: MIEF2
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10066 | duloxetine | Chemical | ClinicalAnnotation | associated | PD | 29407288 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 29407288 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33414447 | 2021 | MIEF2 reprograms lipid metabolism to drive progression of ovarian cancer through ROS/AKT/mTOR signaling pathway. | 42 |
| 33414447 | 2021 | MIEF2 reprograms lipid metabolism to drive progression of ovarian cancer through ROS/AKT/mTOR signaling pathway. | 42 |
| 32068312 | 2020 | An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications. | 9 |
| 32236517 | 2020 | Mitochondrial fragmentation enables localized signaling required for cell repair. | 30 |
| 33317572 | 2020 | MIEF2 over-expression promotes tumor growth and metastasis through reprogramming of glucose metabolism in ovarian cancer. | 14 |
| 32068312 | 2020 | An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications. | 9 |
| 32236517 | 2020 | Mitochondrial fragmentation enables localized signaling required for cell repair. | 30 |
| 33317572 | 2020 | MIEF2 over-expression promotes tumor growth and metastasis through reprogramming of glucose metabolism in ovarian cancer. | 14 |
| 29431643 | 2018 | Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications. | 82 |
| 29899447 | 2018 | Structural basis of mitochondrial receptor binding and constriction by DRP1. | 158 |
| 29431643 | 2018 | Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications. | 82 |
| 29899447 | 2018 | Structural basis of mitochondrial receptor binding and constriction by DRP1. | 158 |
| 28137654 | 2017 | Foxo3a inhibits mitochondrial fission and protects against doxorubicin-induced cardiotoxicity by suppressing MIEF2. | 27 |
| 28137654 | 2017 | Foxo3a inhibits mitochondrial fission and protects against doxorubicin-induced cardiotoxicity by suppressing MIEF2. | 27 |
| 26564796 | 2016 | Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein. | 70 |
Citation
Dessen P
MIEF2 (mitochondrial elongation factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56427/mief2-(mitochondrial-elongation-factor-2)
