IFT20 (intraflagellar transport 20)

2016-10-01  

Identity

HGNC
IFT20
LOCATION
17q11.2
LOCUSID
90410
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 90410
MIM: 614394
HGNC: 30989
Ensembl: ENSG00000109083

Variants:

dbSNP: 90410
ClinVar: 90410
TCGA: ENSG00000109083
COSMIC: IFT20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109083ENST00000357896Q8IY31
ENSG00000109083ENST00000395418Q8IY31
ENSG00000109083ENST00000395418A0A024QZ08
ENSG00000109083ENST00000577498J3KRU2
ENSG00000109083ENST00000578009J3QRH2
ENSG00000109083ENST00000578122J3QRC6
ENSG00000109083ENST00000578985J3QR43
ENSG00000109083ENST00000579419Q8IY31
ENSG00000109083ENST00000585089Q8IY31
ENSG00000109083ENST00000585313Q8IY31
ENSG00000109083ENST00000585313A0A024QZ08
ENSG00000109083ENST00000588477A0A087X2B4

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Intraflagellar transportREACTOMER-HSA-5620924

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
167750042006The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly.231
267157562016IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo.18
281541592017The T cell IFT20 interactome reveals new players in immune synapse assembly.11
292377192018IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.11
290405582018Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.3
307427412019Intraflagellar transport 20 promotes collective cancer cell invasion by regulating polarized organization of Golgi-associated microtubules.1
146724132003Cloning and characterization of the human IFT20 gene.0

Citation

Dessen P

IFT20 (intraflagellar transport 20)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56430/ift20-(intraflagellar-transport-20)