CNOT6L (CCR4-NOT transcription complex subunit 6 like)

2016-10-01  

Identity

HGNC
LOCATION
4q21.1
LOCUSID
ALIAS
CCR4b
FUSION GENES

Other Information

Locus ID:

NCBI: 246175
MIM: 618069
HGNC: 18042
Ensembl: ENSG00000138767

Variants:

dbSNP: 246175
ClinVar: 246175
TCGA: ENSG00000138767
COSMIC: CNOT6L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138767ENST00000504123Q96LI5
ENSG00000138767ENST00000504804D6RIW9
ENSG00000138767ENST00000512485H0Y9Z5
ENSG00000138767ENST00000515441D6RGK9
ENSG00000138767ENST00000515506H0Y9C1
ENSG00000138767ENST00000649644H0Y9Z5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375310262023Exosomal circCNOT6L Regulates Astrocyte Apoptotic Signals Induced by Hypoxia Exposure Through miR99a-5p/SERPINE1 and Alleviates Ischemic Stroke Injury.0
375310262023Exosomal circCNOT6L Regulates Astrocyte Apoptotic Signals Induced by Hypoxia Exposure Through miR99a-5p/SERPINE1 and Alleviates Ischemic Stroke Injury.0
353857052022Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.16
353857052022Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.16
309266672019Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.15
3098454520191-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg(2+)-dependent binding.1
311166652019mRNA levels are buffered upon knockdown of RNA decay and translation factors via adjustment of transcription rates in human HepG2 cells.12
309266672019Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.15
3098454520191-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg(2+)-dependent binding.1
311166652019mRNA levels are buffered upon knockdown of RNA decay and translation factors via adjustment of transcription rates in human HepG2 cells.12
266086072016Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation.3
270130542016Structural basis for inhibition of the deadenylase activity of human CNOT6L.4
266086072016Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation.3
270130542016Structural basis for inhibition of the deadenylase activity of human CNOT6L.4
235918152013Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1.7

Citation

Dessen P

CNOT6L (CCR4-NOT transcription complex subunit 6 like)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56438/cnot6l-(ccr4-not-transcription-complex-subunit-6-like)