GPR37L1 (G protein-coupled receptor 37 like 1)

2016-10-01  

Identity

HGNC
GPR37L1
LOCATION
1q32.1
LOCUSID
9283
ALIAS
ET(B)R-LP-2,ETBR-LP-2,ETBRLP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9283
MIM: 617630
HGNC: 14923
Ensembl: ENSG00000170075

Variants:

dbSNP: 9283
ClinVar: 9283
TCGA: ENSG00000170075
COSMIC: GPR37L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170075ENST00000367282O60883

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385303642024Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis.0
385699272024Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine.0
385303642024Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis.0
385699272024Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine.0
364309342022G Protein-Coupled Receptor 37L1 Modulates Epigenetic Changes in Human Renal Proximal Tubule Cells.2
364309342022G Protein-Coupled Receptor 37L1 Modulates Epigenetic Changes in Human Renal Proximal Tubule Cells.2
341000782021Identification of the GlialCAM interactome: the G protein-coupled receptors GPRC5B and GPR37L1 modulate megalencephalic leukoencephalopathy proteins.6
345334002021Involvement of GPR37L1 in murine blood pressure regulation and human cardiac disease pathophysiology.5
341000782021Identification of the GlialCAM interactome: the G protein-coupled receptors GPRC5B and GPR37L1 modulate megalencephalic leukoencephalopathy proteins.6
345334002021Involvement of GPR37L1 in murine blood pressure regulation and human cardiac disease pathophysiology.5
332039552020The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases.4
332039552020The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases.4
304232892019GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells.10
304232892019GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells.10
286888532017GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.26

Citation

Dessen P

GPR37L1 (G protein-coupled receptor 37 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56441/gpr37l1-(g-protein-coupled-receptor-37-like-1)