PLD6 (phospholipase D family member 6)

2016-10-01  

Identity

HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
ZUC
FUSION GENES

Other Information

Locus ID:

NCBI: 201164
MIM: 614960
HGNC: 30447
Ensembl: ENSG00000179598

Variants:

dbSNP: 201164
ClinVar: 201164
TCGA: ENSG00000179598
COSMIC: PLD6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179598ENST00000321560Q8N2A8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
PIWI-interacting RNA (piRNA) biogenesisREACTOMER-HSA-5601884
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PGREACTOMER-HSA-1483148

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375845892023NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering.4
375845892023NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering.4
343268152021Decreased piRNAs in Infertile Semen Are Related to Downregulation of Sperm MitoPLD Expression.9
343268152021Decreased piRNAs in Infertile Semen Are Related to Downregulation of Sperm MitoPLD Expression.9
267110112016Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis.53
267110112016Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis.53
222810062012Roles for the lipid-signaling enzyme MitoPLD in mitochondrial dynamics, piRNA biogenesis, and spermatogenesis.11
222810062012Roles for the lipid-signaling enzyme MitoPLD in mitochondrial dynamics, piRNA biogenesis, and spermatogenesis.11
213978482011piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling.163
213978482011piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling.163
170285792006A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis.203
170285792006A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis.203

Citation

Dessen P

PLD6 (phospholipase D family member 6)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56451/pld6-(phospholipase-d-family-member-6)