Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57472
MIM: 608951
HGNC: 14099
Ensembl: ENSG00000113300
Variants:
dbSNP: 57472
ClinVar: 57472
TCGA: ENSG00000113300
COSMIC: CNOT6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000113300 | ENST00000261951 | Q9ULM6 |
| ENSG00000113300 | ENST00000393356 | Q9ULM6 |
| ENSG00000113300 | ENST00000504343 | D6R9H6 |
| ENSG00000113300 | ENST00000618123 | Q9ULM6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34038562 | 2021 | Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex. | 10 |
| 34038562 | 2021 | Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex. | 10 |
| 30926667 | 2019 | Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. | 15 |
| 30926667 | 2019 | Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. | 15 |
| 27805284 | 2017 | Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs. | 6 |
| 27805284 | 2017 | Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs. | 6 |
| 26792405 | 2016 | miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways. | 27 |
| 26792405 | 2016 | miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways. | 27 |
| 25944446 | 2015 | The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module. | 18 |
| 25944446 | 2015 | The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module. | 18 |
| 21233283 | 2011 | The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. | 58 |
| 21233283 | 2011 | The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. | 58 |
| 18818012 | 2009 | hCCR4/cNOT6 targets DNA-damage response proteins. | 6 |
| 19558367 | 2009 | Human Ccr4-Not complexes contain variable deadenylase subunits. | 100 |
| 18818012 | 2009 | hCCR4/cNOT6 targets DNA-damage response proteins. | 6 |
Citation
Dessen P
CNOT6 (CCR4-NOT transcription complex subunit 6)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56453/cnot6-(ccr4-not-transcription-complex-subunit-6)
