WDR12 (WD repeat domain 12)

2016-10-01 Affiliation

Identity

HGNC

WDR12

LOCATION

2q33.2

LOCUSID

55759

ALIAS

YTM1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55759
MIM: 616620
HGNC: 14098
Ensembl: ENSG00000138442

Variants:

dbSNP: 55759
ClinVar: 55759
TCGA: ENSG00000138442
COSMIC: WDR12

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000138442	ENST00000261015	Q9GZL7
ENSG00000138442	ENST00000261015	Q53T99

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
rRNA processing	REACTOME	R-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosol	REACTOME	R-HSA-6791226
rRNA processing in the nucleus and cytosol	REACTOME	R-HSA-8868773

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38795544	2024	circMIRIAF aggravates myocardial ischemia-reperfusion injury via targeting miR-544/WDR12 axis.	0
38795544	2024	circMIRIAF aggravates myocardial ischemia-reperfusion injury via targeting miR-544/WDR12 axis.	0
32180229	2020	Integrative genomic analyses identify WDR12 as a novel oncogene involved in glioblastoma.	9
32180229	2020	Integrative genomic analyses identify WDR12 as a novel oncogene involved in glioblastoma.	9
25825154	2015	DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.	18
25915632	2015	WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.	5
25825154	2015	DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.	18
25915632	2015	WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.	5
20738937	2010	Additive effect of multiple genetic variants on the risk of coronary artery disease.	9
20971364	2010	A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.	233
20738937	2010	Additive effect of multiple genetic variants on the risk of coronary artery disease.	9
20971364	2010	A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.	233
19198609	2009	Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.	534
19198609	2009	Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.	534
17353269	2007	Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit.	79

Citation

Dessen P

WDR12 (WD repeat domain 12)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56456/wdr12-(wd-repeat-domain-12)