VAMP4 (vesicle associated membrane protein 4)

2016-10-01  

Identity

HGNC
LOCATION
1q24.3
LOCUSID
ALIAS
VAMP-4,VAMP24

Other Information

Locus ID:

NCBI: 8674
MIM: 606909
HGNC: 12645
Ensembl: ENSG00000117533

Variants:

dbSNP: 8674
ClinVar: 8674
TCGA: ENSG00000117533
COSMIC: VAMP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117533ENST00000236192O75379
ENSG00000117533ENST00000236192Q6IAZ3
ENSG00000117533ENST00000367740O75379
ENSG00000117533ENST00000474047O75379
ENSG00000117533ENST00000474047Q6IAZ3

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
360532152022VAMP4 regulates insulin levels by targeting secretory granules to lysosomes.3
360532152022VAMP4 regulates insulin levels by targeting secretory granules to lysosomes.3
328734362021Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease.9
328734362021Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease.9
235854722013ATP11B mediates platinum resistance in ovarian cancer.29
236776962013VAMP4 is required to maintain the ribbon structure of the Golgi apparatus.17
237413352013Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.16
237985382013Vesicle-associated membrane protein 4 and syntaxin 6 interactions at the chlamydial inclusion.17
235854722013ATP11B mediates platinum resistance in ovarian cancer.29
236776962013VAMP4 is required to maintain the ribbon structure of the Golgi apparatus.17
237413352013Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.16
237985382013Vesicle-associated membrane protein 4 and syntaxin 6 interactions at the chlamydial inclusion.17
224065492012VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.84
224065492012VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.84
218054682011VAMP4- and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cells.23

Citation

Dessen P

VAMP4 (vesicle associated membrane protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56459/vamp4-(vesicle-associated-membrane-protein-4)