VAMP4 (vesicle associated membrane protein 4)

2016-10-01 Affiliation

Identity

HGNC

VAMP4

LOCATION

1q24.3

LOCUSID

8674

ALIAS

VAMP-4,VAMP24

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8674
MIM: 606909
HGNC: 12645
Ensembl: ENSG00000117533

Variants:

dbSNP: 8674
ClinVar: 8674
TCGA: ENSG00000117533
COSMIC: VAMP4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000117533	ENST00000236192	O75379
ENSG00000117533	ENST00000236192	Q6IAZ3
ENSG00000117533	ENST00000367740	O75379
ENSG00000117533	ENST00000474047	O75379
ENSG00000117533	ENST00000474047	Q6IAZ3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
SNARE interactions in vesicular transport	KEGG	ko04130
SNARE interactions in vesicular transport	KEGG	hsa04130
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Retrograde transport at the Trans-Golgi-Network	REACTOME	R-HSA-6811440
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Cargo recognition for clathrin-mediated endocytosis	REACTOME	R-HSA-8856825

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36053215	2022	VAMP4 regulates insulin levels by targeting secretory granules to lysosomes.	3
36053215	2022	VAMP4 regulates insulin levels by targeting secretory granules to lysosomes.	3
32873436	2021	Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease.	9
32873436	2021	Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease.	9
23585472	2013	ATP11B mediates platinum resistance in ovarian cancer.	29
23677696	2013	VAMP4 is required to maintain the ribbon structure of the Golgi apparatus.	17
23741335	2013	Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.	16
23798538	2013	Vesicle-associated membrane protein 4 and syntaxin 6 interactions at the chlamydial inclusion.	17
23585472	2013	ATP11B mediates platinum resistance in ovarian cancer.	29
23677696	2013	VAMP4 is required to maintain the ribbon structure of the Golgi apparatus.	17
23741335	2013	Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.	16
23798538	2013	Vesicle-associated membrane protein 4 and syntaxin 6 interactions at the chlamydial inclusion.	17
22406549	2012	VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.	84
22406549	2012	VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.	84
21805468	2011	VAMP4- and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cells.	23

Citation

Dessen P

VAMP4 (vesicle associated membrane protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56459/vamp4-(vesicle-associated-membrane-protein-4)