SELENOS (selenoprotein S)

2016-10-01  

Identity

HGNC
LOCATION
15q26.3
LOCUSID
ALIAS
AD-015,ADO15,SBBI8,SELS,SEPS1,VIMP

Other Information

Locus ID:

NCBI: 55829
MIM: 607918
HGNC: 30396
Ensembl: ENSG00000131871

Variants:

dbSNP: 55829
ClinVar: 55829
TCGA: ENSG00000131871
COSMIC: SELENOS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131871ENST00000398226Q9BQE4
ENSG00000131871ENST00000526049Q9BQE4
ENSG00000131871ENST00000528346E9PN30
ENSG00000131871ENST00000531964A0A182DWI4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
HRD1/SEL1 ERAD complexKEGGhsa_M00403
HRD1/SEL1 ERAD complexKEGGM00403

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367736922023Selenoprotein S Interacts with the Replication and Transcription Complex of SARS-CoV-2 by Binding nsp7.2
367736922023Selenoprotein S Interacts with the Replication and Transcription Complex of SARS-CoV-2 by Binding nsp7.2
355697652022Selenoprotein S regulates tumorigenesis of clear cell renal cell carcinoma through AKT/ GSK3β/NF-κB signaling pathway.1
370920562022Rs7537605 polymorphism in VAV3 gene and rs28665122 polymorphism in SEPS gene are not associated with Hashimoto's thyroiditis in North-East Algerian population.1
355697652022Selenoprotein S regulates tumorigenesis of clear cell renal cell carcinoma through AKT/ GSK3β/NF-κB signaling pathway.1
370920562022Rs7537605 polymorphism in VAV3 gene and rs28665122 polymorphism in SEPS gene are not associated with Hashimoto's thyroiditis in North-East Algerian population.1
318464352020Selenoprotein S regulates adipogenesis through IRE1α-XBP1 pathway.5
332901402020The SELS rs34713741 Polymorphism Is Associated with Susceptibility to Colorectal Cancer and Gastric Cancer: A Meta-Analysis.5
318464352020Selenoprotein S regulates adipogenesis through IRE1α-XBP1 pathway.5
332901402020The SELS rs34713741 Polymorphism Is Associated with Susceptibility to Colorectal Cancer and Gastric Cancer: A Meta-Analysis.5
300827702019Degradation of selenoprotein S and selenoprotein K through PPARγ-mediated ubiquitination is required for adipocyte differentiation.18
312651772019Correlation between SEPS1 gene polymorphism and type 2 diabetes mellitus: A preliminary study.6
314267182019Interaction of Genetic Variations in NFE2L2 and SELENOS Modulates the Risk of Hashimoto's Thyroiditis.10
315428662019Effect of single nucleotide polymorphisms in SEPS1 and SEPP1 on expression in the protein level in metabolic syndrome in subjects with cardiovascular disease.3
318802142019High glucose and TGF-β1 reduce expression of endoplasmic reticulum-resident selenoprotein S and selenoprotein N in human mesangial cells.6

Citation

Dessen P

SELENOS (selenoprotein S)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56471/selenos-(selenoprotein-s)