Identity
HGNC
LOCATION
22q12.2
LOCUSID
ALIAS
EPI64,TBC1D10,dJ130H16.1,dJ130H16.2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 83874
MIM: 610020
HGNC: 23609
Ensembl: ENSG00000099992
Variants:
dbSNP: 83874
ClinVar: 83874
TCGA: ENSG00000099992
COSMIC: TBC1D10A
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Vesicle-mediated transport | REACTOME | R-HSA-5653656 |
| Membrane Trafficking | REACTOME | R-HSA-199991 |
| TBC/RABGAPs | REACTOME | R-HSA-8854214 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34757852 | 2022 | The RabGAPs EPI64A and EPI64B regulate the apical structure of epithelial cells (†). | 0 |
| 34757852 | 2022 | The RabGAPs EPI64A and EPI64B regulate the apical structure of epithelial cells (†). | 0 |
| 31527750 | 2019 | Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins. | 14 |
| 31527750 | 2019 | Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins. | 14 |
| 28566286 | 2017 | Rab35 protein regulates evoked exocytosis of endothelial Weibel-Palade bodies. | 21 |
| 28566286 | 2017 | Rab35 protein regulates evoked exocytosis of endothelial Weibel-Palade bodies. | 21 |
| 24673604 | 2014 | Rab27A regulates exosome secretion from lung adenocarcinoma cells A549: involvement of EPI64. | 35 |
| 24673604 | 2014 | Rab27A regulates exosome secretion from lung adenocarcinoma cells A549: involvement of EPI64. | 35 |
| 23248241 | 2013 | All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities towards Ras. | 6 |
| 23248241 | 2013 | All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities towards Ras. | 6 |
| 22219378 | 2012 | EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking. | 18 |
| 22219378 | 2012 | EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking. | 18 |
| 20360009 | 2010 | Recycling of the Ca2+-activated K+ channel, KCa2.3, is dependent upon RME-1, Rab35/EPI64C, and an N-terminal domain. | 38 |
| 20360009 | 2010 | Recycling of the Ca2+-activated K+ channel, KCa2.3, is dependent upon RME-1, Rab35/EPI64C, and an N-terminal domain. | 38 |
| 18450757 | 2008 | Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation. | 80 |
Citation
Dessen P
TBC1D10A (TBC1 domain family member 10A)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56475/tbc1d10a-(tbc1-domain-family-member-10a)
