JAML (junction adhesion molecule like)

2016-10-01  

Identity

HGNC
JAML
LOCATION
11q23.3
LOCUSID
120425
ALIAS
AMICA,AMICA1,CREA7-1,CREA7-4,Gm638

Other Information

Locus ID:

NCBI: 120425
MIM: 609770
HGNC: 19084
Ensembl: ENSG00000160593

Variants:

dbSNP: 120425
ClinVar: 120425
TCGA: ENSG00000160593
COSMIC: JAML

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160593ENST00000292067Q86YT9
ENSG00000160593ENST00000356289Q86YT9
ENSG00000160593ENST00000524477E9PNS8
ENSG00000160593ENST00000525565E9PJJ4
ENSG00000160593ENST00000526595E9PKK2
ENSG00000160593ENST00000526620Q86YT9
ENSG00000160593ENST00000527877E9PLF9
ENSG00000160593ENST00000533261E9PR26
ENSG00000160593ENST00000640745A0A1W2PRS4

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385700842024JAML promotes the antitumor role of tumor-resident CD8(+) T cells by facilitating their innate-like function in human lung cancer.0
386254872024JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment.0
385700842024JAML promotes the antitumor role of tumor-resident CD8(+) T cells by facilitating their innate-like function in human lung cancer.0
386254872024JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment.0
370690062023Junctional adhesion molecule-like protein as a novel target for kaempferol to ameliorate lung adenocarcinoma.0
370690062023Junctional adhesion molecule-like protein as a novel target for kaempferol to ameliorate lung adenocarcinoma.0
350340892022Junctional Adhesion Molecule-Like Protein (JAML) Is Correlated with Prognosis and Immune Infiltrates in Lung Adenocarcinoma.3
356727762022Junctional adhesion molecule-like protein promotes tumor progression via the Wnt/β-catenin signaling pathway in lung adenocarcinoma.3
350340892022Junctional Adhesion Molecule-Like Protein (JAML) Is Correlated with Prognosis and Immune Infiltrates in Lung Adenocarcinoma.3
356727762022Junctional adhesion molecule-like protein promotes tumor progression via the Wnt/β-catenin signaling pathway in lung adenocarcinoma.3
344275882021JAML promotes CD8 and γδ T cell antitumor immunity and is a novel target for cancer immunotherapy.8
344275882021JAML promotes CD8 and γδ T cell antitumor immunity and is a novel target for cancer immunotherapy.8
331865582020Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.55
331865582020Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.55
300552892018Junctional adhesion molecules mediate transendothelial migration of dendritic cell vaccine in cancer immunotherapy.4

Citation

Dessen P

JAML (junction adhesion molecule like)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56484/jaml-(junction-adhesion-molecule-like)