SULT1A3 (sulfotransferase family 1A member 3)

2016-10-01  

Identity

HGNC
SULT1A3
LOCATION
16p11.2
LOCUSID
6818
ALIAS
HAST,HAST3,M-PST,ST1A3,ST1A3/ST1A4,ST1A4,ST1A5,STM,TL-PST

Other Information

Locus ID:

NCBI: 6818
MIM: 600641
HGNC: 11455
Ensembl: ENSG00000261052

Variants:

dbSNP: 6818
ClinVar: 6818
TCGA: ENSG00000261052
COSMIC: SULT1A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000261052ENST00000338971P0DMM9
ENSG00000261052ENST00000338971Q1ET61
ENSG00000261052ENST00000395138P0DMM9
ENSG00000261052ENST00000395138Q1ET61
ENSG00000261052ENST00000563322P0DMM9
ENSG00000261052ENST00000563638H3BRT0
ENSG00000261052ENST00000569485H3BPL6

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Cytosolic sulfonation of small moleculesREACTOMER-HSA-156584

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166131379o-desmethyl-tramadolChemicalClinicalAnnotation, VariantAnnotationassociatedPK
PA166179720tapentadolChemicalClinicalAnnotation, VariantAnnotationassociatedPK
PA448015acetaminophenChemicalClinicalAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotationassociatedPK23462933, 26049587
PA450550morphineChemicalClinicalAnnotation, VariantAnnotationambiguousPK
PA451735tramadolChemicalClinicalAnnotationassociatedPK

References

Pubmed IDYearTitleCitations
374876592023Farnesoid X receptor represses human sulfotransferase 1A3 expression through direct binding to the promoter.0
380692212023Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.0
374876592023Farnesoid X receptor represses human sulfotransferase 1A3 expression through direct binding to the promoter.0
380692212023Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.0
321520502020Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.6
321520502020Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.6
311457022019Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes.2
311457022019Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes.2
283748582018Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease.11
297052712018Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3.7
283748582018Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease.11
297052712018Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3.7
286302922017Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.12
290253752017Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma.14
286302922017Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.12

Citation

Dessen P

SULT1A3 (sulfotransferase family 1A member 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56490/sult1a3-(sulfotransferase-family-1a-member-3)