IFNL4 (interferon lambda 4 (gene/pseudogene))

2016-10-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
IFNAN

Other Information

Locus ID:

NCBI: 101180976
MIM: 615090
HGNC: 44480
Ensembl: ENSG00000272395

Variants:

dbSNP: 101180976
ClinVar: 101180976
TCGA: ENSG00000272395
COSMIC: IFNL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000272395ENST00000616270K9M1A9

Expression (GTEx)

0
1

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164749390peginterferon alfa-2aChemicalClinicalAnnotationassociatedPD19684573, 20399780, 20578254, 20621700, 20648473, 20728570, 20804372, 20964522, 21068134, 21112657, 21145807, 21246582, 21374656, 21447862, 21466653, 21537116, 21572301, 21606533, 21726252, 21907615, 21911885, 21951981, 21993426, 22345656, 22438096, 22863269, 23142377, 23321318, 23383658, 23490377, 24072198, 24102823, 24117654, 24308755, 24602923, 24768758, 24907224, 25080450, 25534433, 25918016, 25958342, 26032235, 26284539, 26902034, 27027531, 27498543, 27514956, 27714501, 27833958, 28072888, 28261910, 28453395, 28703131, 28739427, 29369421, 30016335, 30450628, 31201901
PA164784024peginterferon alfa-2bChemicalClinicalAnnotationassociatedPD19684573, 20399780, 20578254, 20621700, 20648473, 20728570, 20804372, 20964522, 21068134, 21112657, 21145807, 21246582, 21374656, 21447862, 21466653, 21537116, 21572301, 21606533, 21726252, 21907615, 21911885, 21951981, 21993426, 22345656, 22438096, 22626609, 22863269, 23142377, 23321318, 23383658, 23490377, 24072198, 24102823, 24117654, 24308755, 24602923, 24768758, 24907224, 25080450, 25534433, 25918016, 25958342, 26032235, 26284539, 26902034, 27027531, 27498543, 27514956, 27714501, 27833958, 28072888, 28261910, 28703131, 28739427, 29369421, 30450628
PA165948902boceprevirChemicalClinicalAnnotationassociatedPD22626609
PA165958354telaprevirChemicalClinicalAnnotationassociatedPD20648473, 21246582, 23321318, 24117654
PA166122590simeprevirChemicalClinicalAnnotationassociatedPD24602923, 24907224, 27027531, 28072888
PA166122593sofosbuvirChemicalClinicalAnnotation, LabelAnnotation, VariantAnnotationassociatedPD25734178, 27357737, 28100007, 29107709, 29534310, 29866411, 30431653, 31260374
PA166128130deleobuvirChemicalClinicalAnnotationassociatedPD23944300
PA166128132faldaprevirChemicalClinicalAnnotationassociatedPD23944300
PA166128166ledipasvirChemicalClinicalAnnotationassociatedPD25734178, 27357737, 28100007
PA166128167daclatasvirChemicalClinicalAnnotation, VariantAnnotationassociatedPD25080450, 30431653
PA166131629sustained virological response (svr)DiseaseVariantAnnotationassociatedPD30431653
PA166155468rs12979860VariantLabelAnnotationassociated
PA166163408ombitasvir / paritaprevir / ritonavirChemicalLabelAnnotationassociated
PA166163415velpatasvirChemicalClinicalAnnotationassociatedPD29107709
PA166171182voxilaprevirChemicalClinicalAnnotationassociatedPD29107709
PA166179660direct acting antiviralsChemicalClinicalAnnotationassociatedPD29866411, 31260374
PA444445Hepatitis CDiseaseClinicalAnnotationassociatedPD19684573, 20399780, 20578254, 20621700, 20728570, 20804372, 20964522, 21068134, 21112657, 21145807, 21374656, 21447862, 21466653, 21537116, 21572301, 21606533, 21726252, 21907615, 21911885, 21951981, 21993426, 22345656, 22438096, 22863269, 23142377, 23321318, 23383658, 23490377, 24072198, 24102823, 24117654, 24308755, 24768758, 25918016, 25958342, 26032235, 26284539, 26902034, 27498543, 27514956, 27714501, 27833958, 28261910, 28703131, 28739427, 30450628
PA445016Myeloproliferative DisordersDiseaseClinicalAnnotationassociatedPD29369421
PA445506RecurrenceDiseaseClinicalAnnotationassociatedPD28100007
PA446862Hepatitis B, ChronicDiseaseClinicalAnnotationassociatedPD28453395, 30016335, 31201901
PA446863Hepatitis C, ChronicDiseaseClinicalAnnotation, VariantAnnotationassociatedPD20648473, 21246582, 22626609, 23321318, 23944300, 24117654, 24602923, 24907224, 25080450, 25534433, 25734178, 27027531, 27357737, 28072888, 28100007, 29107709, 29534310, 29866411, 30431653, 31260374
PA451241ribavirinChemicalClinicalAnnotationassociatedPD19684573, 20399780, 20578254, 20621700, 20648473, 20728570, 20804372, 20964522, 21068134, 21112657, 21145807, 21246582, 21374656, 21447862, 21466653, 21537116, 21572301, 21606533, 21726252, 21907615, 21911885, 21951981, 21993426, 22345656, 22438096, 22626609, 22863269, 23142377, 23321318, 23383658, 23490377, 24072198, 24102823, 24117654, 24308755, 24602923, 24768758, 24907224, 25080450, 25534433, 25918016, 25958342, 26032235, 26284539, 26902034, 27027531, 27498543, 27514956, 27714501, 27833958, 28072888, 28261910, 28703131, 28739427, 30450628
PA451999interferonsChemicalClinicalAnnotationassociatedPD22438096

References

Pubmed IDYearTitleCitations
365732832023No Association of IFNL4 Genotype With Opportunistic Infections and Cancers Among Men With Human Immunodeficiency Virus 1 Infection.1
365923872023Genetic polymorphisms of Endoplasmic reticulum amino peptidase 1 (ERAP1) and Interferon lambda 4 (IFN-λ4) in Egyptian patients with type 1 diabetes mellitus.0
366557492023IFNL3/4 polymorphisms as a two-edged sword: An association with COVID-19 outcome.2
367433062023Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.0
367433822023Relevance of HLA-DP/DQ and INF-λ4 Polymorphisms to COVID-19 Outcomes.1
368809612023A Novel Inactive Isoform with a Restored Reading Frame Is Expressed from the Human Interferon Lambda 4 TT Allele at rs368234815.1
370988522023Pharmacogenetics of tenofovir clearance among Southern Africans living with HIV.0
373668022023IFNL4 Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa.1
380030182023Variants of IFNL4 Gene in Amazonian and Northern Brazilian Populations.0
365732832023No Association of IFNL4 Genotype With Opportunistic Infections and Cancers Among Men With Human Immunodeficiency Virus 1 Infection.1
365923872023Genetic polymorphisms of Endoplasmic reticulum amino peptidase 1 (ERAP1) and Interferon lambda 4 (IFN-λ4) in Egyptian patients with type 1 diabetes mellitus.0
366557492023IFNL3/4 polymorphisms as a two-edged sword: An association with COVID-19 outcome.2
367433062023Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.0
367433822023Relevance of HLA-DP/DQ and INF-λ4 Polymorphisms to COVID-19 Outcomes.1
368809612023A Novel Inactive Isoform with a Restored Reading Frame Is Expressed from the Human Interferon Lambda 4 TT Allele at rs368234815.1

Citation

Dessen P

IFNL4 (interferon lambda 4 (gene/pseudogene))

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56497/gene-explorer/teaching-explorer/