SH3BGRL3 (SH3 domain binding glutamate rich protein like 3)

2016-10-01  

Identity

HGNC
SH3BGRL3
LOCATION
1p36.11
LOCUSID
83442
ALIAS
HEL-S-297,SH3BP-1,TIP-B1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83442
MIM: 615679
HGNC: 15568
Ensembl: ENSG00000142669

Variants:

dbSNP: 83442
ClinVar: 83442
TCGA: ENSG00000142669
COSMIC: SH3BGRL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142669ENST00000270792Q9H299
ENSG00000142669ENST00000319041Q5T123

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
338394062021SH3BGRL3, transcribed by STAT3, facilitates glioblastoma tumorigenesis by activating STAT3 signaling.6
343804382021SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line.2
338394062021SH3BGRL3, transcribed by STAT3, facilitates glioblastoma tumorigenesis by activating STAT3 signaling.6
343804382021SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line.2
323810432020SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane.8
323810432020SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane.8
262869132015SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor.26
262869132015SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor.26
159074822005NMR structure and regulated expression in APL cell of human SH3BGRL3.6
159074822005NMR structure and regulated expression in APL cell of human SH3BGRL3.6

Citation

Dessen P

SH3BGRL3 (SH3 domain binding glutamate rich protein like 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56502/gene-fusions/gene-explorer/meetings/