TRAPPC3 (trafficking protein particle complex subunit 3)

2016-10-01

Identity

HGNC

TRAPPC3

LOCATION

1p34.3

LOCUSID

27095

ALIAS

BET3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 27095
MIM: 610955
HGNC: 19942
Ensembl: ENSG00000054116

Variants:

dbSNP: 27095
ClinVar: 27095
TCGA: ENSG00000054116
COSMIC: TRAPPC3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000054116	ENST00000373159	A6NKE1
ENSG00000054116	ENST00000373162	O43617
ENSG00000054116	ENST00000373163	O43617
ENSG00000054116	ENST00000373166	O43617
ENSG00000054116	ENST00000616074	A0A087WYS5
ENSG00000054116	ENST00000616395	A0A087WWM0
ENSG00000054116	ENST00000617904	O43617

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Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
COPII (Coat Protein 2) Mediated Vesicle Transport	REACTOME	R-HSA-204005
ER to Golgi Anterograde Transport	REACTOME	R-HSA-199977
Membrane Trafficking	REACTOME	R-HSA-199991
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
RAB GEFs exchange GTP for GDP on RABs	REACTOME	R-HSA-8876198
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
Vesicle-mediated transport	REACTOME	R-HSA-5653656

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15692564	2005	Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.	22
15692564	2005	Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.	22
15728249	2005	Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus.	18
15728249	2005	Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus.	18
16828797	2006	Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2.	17
16828797	2006	Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2.	17
16880271	2006	mBet3p is required for homotypic COPII vesicle tethering in mammalian cells.	45
16880271	2006	mBet3p is required for homotypic COPII vesicle tethering in mammalian cells.	45
16908848	2006	Unique self-palmitoylation activity of the transport protein particle component Bet3: a mechanism required for protein stability.	17
16908848	2006	Unique self-palmitoylation activity of the transport protein particle component Bet3: a mechanism required for protein stability.	17

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Citation

Dessen P

TRAPPC3 (trafficking protein particle complex subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56508/trappc3-(trafficking-protein-particle-complex-subunit-3)