Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11252
MIM: 604960
HGNC: 8571
Ensembl: ENSG00000100266
Variants:
dbSNP: 11252
ClinVar: 11252
TCGA: ENSG00000100266
COSMIC: PACSIN2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Vesicle-mediated transport | REACTOME | R-HSA-5653656 |
| Membrane Trafficking | REACTOME | R-HSA-199991 |
| Clathrin-mediated endocytosis | REACTOME | R-HSA-8856828 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Disease | ClinicalAnnotation | associated | PK | PD | 22846425, 27452984 |
| PA450379 | mercaptopurine | Chemical | ClinicalAnnotation | associated | PK | PD | 22846425, 27452984 |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PK | PD | 22846425 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36596605 | 2023 | PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells. | 0 |
| 37132654 | 2023 | Pacsin 2-dependent N-cadherin internalization regulates the migration behaviour of malignant cancer cells. | 3 |
| 36596605 | 2023 | PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells. | 0 |
| 37132654 | 2023 | Pacsin 2-dependent N-cadherin internalization regulates the migration behaviour of malignant cancer cells. | 3 |
| 35352878 | 2022 | Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia. | 2 |
| 35352878 | 2022 | Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia. | 2 |
| 33972531 | 2021 | A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis. | 16 |
| 34325130 | 2021 | Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes. | 2 |
| 33972531 | 2021 | A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis. | 16 |
| 34325130 | 2021 | Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes. | 2 |
| 31792371 | 2020 | PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients. | 8 |
| 31801866 | 2020 | PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly. | 8 |
| 31792371 | 2020 | PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients. | 8 |
| 31801866 | 2020 | PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly. | 8 |
| 31242077 | 2019 | RNAi screen reveals a role for PACSIN2 and caveolins during bacterial cell-to-cell spread. | 8 |
Citation
Dessen P
PACSIN2 (protein kinase C and casein kinase substrate in neurons 2)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56519/pacsin2-(protein-kinase-c-and-casein-kinase-substrate-in-neurons-2)
