CDCA7L (cell division cycle associated 7 like)

2016-10-01  

Identity

HGNC
LOCATION
7p15.3
LOCUSID
ALIAS
JPO2,R1,RAM2
FUSION GENES

Other Information

Locus ID:

NCBI: 55536
MIM: 609685
HGNC: 30777
Ensembl: ENSG00000164649

Variants:

dbSNP: 55536
ClinVar: 55536
TCGA: ENSG00000164649
COSMIC: CDCA7L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164649ENST00000356195Q96GN5
ENSG00000164649ENST00000373934Q96GN5
ENSG00000164649ENST00000406877Q96GN5
ENSG00000164649ENST00000406877A0A024RA51
ENSG00000164649ENST00000435031C9JFL7
ENSG00000164649ENST00000435717H7C1J6
ENSG00000164649ENST00000447180C9J8L0
ENSG00000164649ENST00000457951C9IZR6

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
168295762006Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway.55
167284022006Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1.51
176694262007Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.37
216547402011The reduction of R1, a novel repressor protein for monoamine oxidase A, in major depressive disorder.30
262459782015Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.16
254804952015The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells.11
278829332016Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression.9
270131962016JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma.6
246342102014Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin.4
306203902019Distinct genome-wide methylation patterns in sporadic and hereditary nonfunctioning pancreatic neuroendocrine tumors.3

Citation

Dessen P

CDCA7L (cell division cycle associated 7 like)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56537/cdca7l-(cell-division-cycle-associated-7-like)