Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4014
MIM: 152445
HGNC: 6663
Ensembl: ENSG00000203782
Variants:
dbSNP: 4014
ClinVar: 4014
TCGA: ENSG00000203782
COSMIC: LORICRIN
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000203782 | ENST00000368742 | P23490 |
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Keratinization | REACTOME | R-HSA-6805567 |
| Formation of the cornified envelope | REACTOME | R-HSA-6809371 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37298411 | 2023 | The Epidermal Transcriptome Analysis of a Novel c.639_642dup LORICRIN Variant-Delineation of the Loricrin Keratoderma Pathology. | 0 |
| 37298411 | 2023 | The Epidermal Transcriptome Analysis of a Novel c.639_642dup LORICRIN Variant-Delineation of the Loricrin Keratoderma Pathology. | 0 |
| 35346558 | 2022 | The c.323 G>C mutation in LORICRIN causes new-found late-onset autosomal dominant loricrin keratoderma in a Chinese Han Pedigree. | 1 |
| 35346558 | 2022 | The c.323 G>C mutation in LORICRIN causes new-found late-onset autosomal dominant loricrin keratoderma in a Chinese Han Pedigree. | 1 |
| 31056744 | 2020 | Epidermal autophagy and beclin 1 regulator 1 and loricrin: a paradigm shift in the prognostication and stratification of the American Joint Committee on Cancer stage I melanomas. | 9 |
| 32751111 | 2020 | Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis. | 112 |
| 31056744 | 2020 | Epidermal autophagy and beclin 1 regulator 1 and loricrin: a paradigm shift in the prognostication and stratification of the American Joint Committee on Cancer stage I melanomas. | 9 |
| 32751111 | 2020 | Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis. | 112 |
| 31322196 | 2019 | Effect of S100A8 and S100A9 on expressions of cytokine and skin barrier protein in human keratinocytes. | 20 |
| 31322196 | 2019 | Effect of S100A8 and S100A9 on expressions of cytokine and skin barrier protein in human keratinocytes. | 20 |
| 25142840 | 2015 | A novel microdeletion in LOR causing autosomal dominant loricrin keratoderma. | 2 |
| 25234742 | 2015 | Two novel mutations in the LOR gene in three families with loricrin keratoderma. | 4 |
| 25896246 | 2015 | Barrier Function of the Repaired Skin Is Disrupted Following Arrest of Dicer in Keratinocytes. | 32 |
| 25965869 | 2015 | Novel autosomal dominant mutation in loricrin presenting as prominent ichthyosis. | 4 |
| 26381575 | 2015 | Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1α, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes. | 8 |
Citation
Dessen P
LORICRIN (loricrin cornified envelope precursor protein)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56547/loricrin-(loricrin-cornified-envelope-precursor-protein)
