Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 946
MIM: 604405
HGNC: 10875
Ensembl: ENSG00000105492
Variants:
dbSNP: 946
ClinVar: 946
TCGA: ENSG00000105492
COSMIC: SIGLEC6
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Adaptive Immune System | REACTOME | R-HSA-1280218 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | REACTOME | R-HSA-198933 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35953001 | 2023 | Expression and regulation of Siglec-6 (CD327) on human mast cells and basophils. | 6 |
| 37087495 | 2023 | Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket. | 4 |
| 35953001 | 2023 | Expression and regulation of Siglec-6 (CD327) on human mast cells and basophils. | 6 |
| 37087495 | 2023 | Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket. | 4 |
| 34147404 | 2022 | Siglec-6 as a New Potential Immune Checkpoint for Bladder Cancer Patients. | 6 |
| 35406705 | 2022 | Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells. | 14 |
| 36113626 | 2022 | Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/β-catenin signaling in preeclampsia. | 3 |
| 36359823 | 2022 | Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment. | 4 |
| 34147404 | 2022 | Siglec-6 as a New Potential Immune Checkpoint for Bladder Cancer Patients. | 6 |
| 35406705 | 2022 | Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells. | 14 |
| 36113626 | 2022 | Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/β-catenin signaling in preeclampsia. | 3 |
| 36359823 | 2022 | Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment. | 4 |
| 32998819 | 2020 | Glycosylated Siglec-6 expression in syncytiotrophoblast-derived extracellular vesicles from preeclampsia placentas. | 6 |
| 32998819 | 2020 | Glycosylated Siglec-6 expression in syncytiotrophoblast-derived extracellular vesicles from preeclampsia placentas. | 6 |
| 30294327 | 2018 | Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells. | 30 |
Citation
Dessen P
SIGLEC6 (sialic acid binding Ig like lectin 6)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56555/siglec6-(sialic-acid-binding-ig-like-lectin-6)
