SESN3 (sestrin 3)

2016-10-01  

Identity

HGNC
LOCATION
11q21
LOCUSID
ALIAS
SEST3

Other Information

Locus ID:

NCBI: 143686
MIM: 607768
HGNC: 23060
Ensembl: ENSG00000149212

Variants:

dbSNP: 143686
ClinVar: 143686
TCGA: ENSG00000149212
COSMIC: SESN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149212ENST00000278499P58005
ENSG00000149212ENST00000416495P58005
ENSG00000149212ENST00000536441P58005
ENSG00000149212ENST00000542176F5H1K7
ENSG00000149212ENST00000634898A0A0U1RR17

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
p53 signaling pathwayKEGGhsa04115
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Longevity regulating pathwayKEGGhsa04211

References

Pubmed IDYearTitleCitations
379185782023Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation.0
379185782023Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation.0
349799142022The functions and roles of sestrins in regulating human diseases.23
349799142022The functions and roles of sestrins in regulating human diseases.23
330825542021Colon and liver tissue damage detection using methylated SESN3 and PTK2B genes in circulating cell-free DNA in patients with acute graft-versus-host disease.5
344099222021Oncogenic role of early growth response-1 in liver cancer through the regulation of the microRNA-675/sestrin 3 and the Wnt/β-catenin signaling pathway.8
330825542021Colon and liver tissue damage detection using methylated SESN3 and PTK2B genes in circulating cell-free DNA in patients with acute graft-versus-host disease.5
344099222021Oncogenic role of early growth response-1 in liver cancer through the regulation of the microRNA-675/sestrin 3 and the Wnt/β-catenin signaling pathway.8
326265412020Circulating Sestrin Levels Are Increased in Hypertension Patients.9
326265412020Circulating Sestrin Levels Are Increased in Hypertension Patients.9
310738872019Interactions between microRNA-200 family and Sestrin proteins in endometrial cancer cell lines and their significance to anoikis.11
310738872019Interactions between microRNA-200 family and Sestrin proteins in endometrial cancer cell lines and their significance to anoikis.11
291917712018Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.22
299667502018Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging.10
291917712018Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.22

Citation

Dessen P

SESN3 (sestrin 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56562/sesn3-(sestrin-3)