SGSM2 (small G protein signaling modulator 2)

2016-10-01  

Identity

HGNC
SGSM2
LOCATION
17p13.3
LOCUSID
9905
ALIAS
RUTBC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9905
MIM: 611418
HGNC: 29026
Ensembl: ENSG00000141258

Variants:

dbSNP: 9905
ClinVar: 9905
TCGA: ENSG00000141258
COSMIC: SGSM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141258ENST00000268989O43147
ENSG00000141258ENST00000426855O43147
ENSG00000141258ENST00000426855B9A6J3
ENSG00000141258ENST00000570431I3L361
ENSG00000141258ENST00000572875I3L1Y7
ENSG00000141258ENST00000572925I3NI18
ENSG00000141258ENST00000573062V9GYJ0
ENSG00000141258ENST00000573851J3QSA2
ENSG00000141258ENST00000574563O43147
ENSG00000141258ENST00000574650V9GYD2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
218080682011RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.26
175098192007Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.22
266205602016RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.9
307444932019Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.0

Citation

Dessen P

SGSM2 (small G protein signaling modulator 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56587/sgsm2-(small-g-protein-signaling-modulator-2)